Projects per year
Abstract
A facile and efficient Cu(I)-catalyzed cross-coupling method is reported for the preparation of N-alkynyl or N-bromoalkenyl heteroarenes from bromoalkynes.
Generally superior yields and functional group tolerance were obtained with microwave (MW) irradiation using imidazole, benzimidazole, pyrazole, and indazole substrates and poly(ethylene glycol) 400 (PEG400) as an additive.We speculate that PEG400 acts as both a Cu(I)-stabilizing ligand as well as a phase transfer solvent.
Generally superior yields and functional group tolerance were obtained with microwave (MW) irradiation using imidazole, benzimidazole, pyrazole, and indazole substrates and poly(ethylene glycol) 400 (PEG400) as an additive.We speculate that PEG400 acts as both a Cu(I)-stabilizing ligand as well as a phase transfer solvent.
| Original language | English |
|---|---|
| Pages (from-to) | 980-983 |
| Number of pages | 4 |
| Journal | Journal of Organic Chemistry |
| Volume | 75 |
| Issue number | 3 |
| Early online date | 4 Jan 2010 |
| DOIs | |
| Publication status | Published - 5 Feb 2010 |
Keywords
- phase transfer solvent
- microwave irradiation
- bromoalkynes
- N-alkynyl
- N-bromoalkenyl heteroarenes
Fingerprint Dive into the research topics of 'Cu-Catalyzed N-Alkynylation of imidazoles, benzimidazoles, indazoles, and pyrazoles using PEG as solvent medium'. Together they form a unique fingerprint.
Projects
- 1 Finished
New Molecular Tools For The 21st Century: Molecular Design Of New DNA-Based Devices
EPSRC (Engineering and Physical Sciences Research Council)
1/04/12 → 31/03/13
Project: Research Fellowship
Cite this
Burley, G., Davies, D. L., Griffith, G. A., Lee, M., & Singh, K. (2010). Cu-Catalyzed N-Alkynylation of imidazoles, benzimidazoles, indazoles, and pyrazoles using PEG as solvent medium. Journal of Organic Chemistry, 75(3), 980-983. https://doi.org/10.1021/jo902466f