Crystallization and preliminary crystallographic studies of antibacterial polypeptide LCI expressed in Escherichia coli

Jia-Peng Zhu, Bing-Zhang Chen, Wei-Bin Gong, Yu-He Liang, Huan-Chen Wang, Qing Xu, Zhang-Liang Chen, Guang-Ying Lu

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Abstract

LCI is a type of novel antibacterial polypeptide secreted by a Bacillus subtilis strain. It consists of 47 residues with a molecular weight of 5468 Da. Using bioengineering, LCI was expressed in Escherichia coli DH5α with recombinant plasmid pBVAB16. It was crystallized using PEG 4000 as a precipitant. The crystal belongs to space group P6222 or P6422, with unit-cell parameters a = b = 29.30, c = 187.09 Å, and diffracts to 2.44 Å. A set of diffraction data to 2.8 Å was collected.

Original languageEnglish
Pages (from-to)1931-1932
Number of pages2
JournalActa Crystallographica Section D: Biological Crystallography
VolumeD57
Issue number12
DOIs
Publication statusPublished - 1 Dec 2001

Keywords

  • antibacterial polypeptide
  • Escherichia coli
  • Bacillus subtilis strain
  • LCI

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