Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

Francesca P.A. Fabbiani; Birger Dittrich; A.J. Florence; T. Gelbrich; M.B. Hursthouse; Werner F. Kuhs; N. Shankland; Heidrum Sowa

doi:10.1039/b822987b

Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

Francesca P.A. Fabbiani, Birger Dittrich, A.J. Florence, T. Gelbrich, M.B. Hursthouse, Werner F. Kuhs, N. Shankland, Heidrum Sowa

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.

Original language	English
Pages (from-to)	1396-1406
Number of pages	10
Journal	CrystEngComm
Volume	11
DOIs	https://doi.org/10.1039/b822987b
Publication status	Published - 2008

Keywords

crystal structures
high-pressure crystallisation
ciprofloxacin sodium salts
ambient pressure
biomedical sciences

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10.1039/b822987b

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)
Murphy, J. (Principal Investigator), Coombs, G. (Co-investigator), Ferguson, A. (Co-investigator) & Florence, A. (Co-investigator)
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/09/07 → 30/10/12
Project: Research

Cite this

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abstract = "Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.",

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language = "English",

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pages = "1396--1406",

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T1 - Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

AU - Fabbiani, Francesca P.A.

AU - Dittrich, Birger

AU - Florence, A.J.

AU - Gelbrich, T.

AU - Hursthouse, M.B.

AU - Kuhs, Werner F.

AU - Shankland, N.

AU - Sowa, Heidrum

PY - 2008

Y1 - 2008

N2 - Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.

AB - Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.

KW - crystal structures

KW - high-pressure crystallisation

KW - ciprofloxacin sodium salts

KW - ambient pressure

KW - biomedical sciences

U2 - 10.1039/b822987b

DO - 10.1039/b822987b

M3 - Article

SN - 1466-8033

VL - 11

SP - 1396

EP - 1406

JO - CrystEngComm

JF - CrystEngComm

ER -

Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure

Abstract

Keywords

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Projects

Physical Organic Chemistry: Opportunities In Synthesis, Materials And Pharmaceuticals (Science And Innovation Award)

Cite this