Abstract
The most potent inhibitor of Sphingosine Kinase 1 (SPHK1) so far identified is PF-543. The crystal structure of SPHK1 in complex with inhibitor PF-543 to 1.8 Å resolution reveals the inhibitor bound in a bent conformation analogous to that expected of a bound sphingosine substrate but with a rotated head group. The structural data presented will aid in the design of SPHK1 and SPHK2 inhibitors with improved properties.
Original language | English |
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Pages (from-to) | 1329-1333 |
Number of pages | 5 |
Journal | Medicinal Chemistry Letters |
Volume | 5 |
Issue number | 12 |
Early online date | 27 Oct 2014 |
DOIs | |
Publication status | Published - 27 Dec 2014 |
Keywords
- SPHK1
- PF-543
- SPHK2
- sphingosine
- lipid
- S1P