Crystal structure of a mixed solvated form of amoxapine acetate

Rajni M. Bhardwaj, Vishal Raval, Iain D. H. Oswald, Alastair J. Florence, H. Stoeckli-Evans (Editor)

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Abstract

The mixed solvated salt 4-(2-chloro­dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate-acetic acid-cyclo­hexane (2/2/1), C17H17ClN3O+·C2H3O2-·C2H4O2·0.5C6H12, crystallizes with one mol­ecule of protonated amoxapine (AXPN), an acetate anion and a mol­ecule of acetic acid together with half a mol­ecule of cyclo­hexane. In the centrosymmetric crystal, both enanti­omers of the protonated AXPN mol­ecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N-H...O hydrogen bonding in the [010] direction, creating a sheet lying parallel to (100). The acetic acid mol­ecules are linked to the acetate anions via O-H...O hydrogen bonds within the sheets. Within the sheets there are also a number of C-H...O hydrogen bonds present. The cyclo­hexane solvent mol­ecules occupy the space between the sheets.

Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalActa Crystallographica Section E: Structure Reports
Volume71
Issue number2
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • amoxapine
  • crystal structure
  • hydrogen bonding
  • mixed solvate
  • oxaze-pine

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