Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead; Kenneth A. Johnson; James H. Kowatz; Stephen A. McMahon; Lester G. Carter; Muse Oke; Huanting Liu; James H. Naismith; Christopher F. van der Walle

doi:10.1039/b718264c

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead
, Kenneth A. Johnson
, James H. Kowatz
, Stephen A. McMahon
, Lester G. Carter
, Muse Oke
, Huanting Liu
, James H. Naismith
, Christopher F. van der Walle

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

Original language	English
Pages (from-to)	1765-1767
Number of pages	2
Journal	Chemical Communications (London)
Volume	2008
Issue number	15
DOIs	https://doi.org/10.1039/b718264c
Publication status	Published - 21 Apr 2008

Keywords

crystal structures
silica
condensation
silicatein –cathepsin L chimeras
pharmacology
chemistry

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10.1039/b718264c

Cite this

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title = "Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras",

abstract = "Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.",

keywords = "crystal structures, silica, condensation, silicatein –cathepsin L chimeras, pharmacology, chemistry",

author = "Michael Fairhead and Johnson, \{Kenneth A.\} and Kowatz, \{James H.\} and McMahon, \{Stephen A.\} and Carter, \{Lester G.\} and Muse Oke and Huanting Liu and Naismith, \{James H.\} and \{van der Walle\}, \{Christopher F.\}",

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T1 - Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

AU - Fairhead, Michael

AU - Johnson, Kenneth A.

AU - Kowatz, James H.

AU - McMahon, Stephen A.

AU - Carter, Lester G.

AU - Oke, Muse

AU - Liu, Huanting

AU - Naismith, James H.

AU - van der Walle, Christopher F.

PY - 2008/4/21

Y1 - 2008/4/21

N2 - Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

AB - Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

KW - crystal structures

KW - silica

KW - condensation

KW - silicatein –cathepsin L chimeras

KW - pharmacology

KW - chemistry

U2 - 10.1039/b718264c

DO - 10.1039/b718264c

M3 - Article

SN - 0009-241X

VL - 2008

SP - 1765

EP - 1767

JO - Chemical Communications (London)

JF - Chemical Communications (London)

IS - 15

ER -

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Abstract

Keywords

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