Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead, Kenneth A. Johnson, James H. Kowatz, Stephen A. McMahon, Lester G. Carter, Muse Oke, Huanting Liu, James H. Naismith, Christopher F. van der Walle

Research output: Contribution to journalArticle

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Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.
LanguageEnglish
Pages1765-1767
Number of pages2
JournalChemical Communications (London)
Volume2008
Issue number15
DOIs
Publication statusPublished - 21 Apr 2008

Fingerprint

Silicic Acid
Cathepsin L
Silicon Dioxide
Condensation
Crystal structure
silicatein alpha

Keywords

  • crystal structures
  • silica
  • condensation
  • silicatein –cathepsin L chimeras
  • pharmacology
  • chemistry

Cite this

Fairhead, M., Johnson, K. A., Kowatz, J. H., McMahon, S. A., Carter, L. G., Oke, M., ... van der Walle, C. F. (2008). Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chemical Communications (London), 2008(15), 1765-1767. https://doi.org/10.1039/b718264c
Fairhead, Michael ; Johnson, Kenneth A. ; Kowatz, James H. ; McMahon, Stephen A. ; Carter, Lester G. ; Oke, Muse ; Liu, Huanting ; Naismith, James H. ; van der Walle, Christopher F. / Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. In: Chemical Communications (London). 2008 ; Vol. 2008, No. 15. pp. 1765-1767.
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Fairhead, M, Johnson, KA, Kowatz, JH, McMahon, SA, Carter, LG, Oke, M, Liu, H, Naismith, JH & van der Walle, CF 2008, 'Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras' Chemical Communications (London), vol. 2008, no. 15, pp. 1765-1767. https://doi.org/10.1039/b718264c

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. / Fairhead, Michael; Johnson, Kenneth A.; Kowatz, James H.; McMahon, Stephen A.; Carter, Lester G.; Oke, Muse; Liu, Huanting; Naismith, James H.; van der Walle, Christopher F.

In: Chemical Communications (London), Vol. 2008, No. 15, 21.04.2008, p. 1765-1767.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

AU - Fairhead, Michael

AU - Johnson, Kenneth A.

AU - Kowatz, James H.

AU - McMahon, Stephen A.

AU - Carter, Lester G.

AU - Oke, Muse

AU - Liu, Huanting

AU - Naismith, James H.

AU - van der Walle, Christopher F.

PY - 2008/4/21

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AB - Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

KW - crystal structures

KW - silica

KW - condensation

KW - silicatein –cathepsin L chimeras

KW - pharmacology

KW - chemistry

U2 - 10.1039/b718264c

DO - 10.1039/b718264c

M3 - Article

VL - 2008

SP - 1765

EP - 1767

JO - Chemical Communications (London)

T2 - Chemical Communications (London)

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SN - 0009-241X

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Fairhead M, Johnson KA, Kowatz JH, McMahon SA, Carter LG, Oke M et al. Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chemical Communications (London). 2008 Apr 21;2008(15):1765-1767. https://doi.org/10.1039/b718264c