Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead, Kenneth A. Johnson, James H. Kowatz, Stephen A. McMahon, Lester G. Carter, Muse Oke, Huanting Liu, James H. Naismith, Christopher F. van der Walle

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.
Original languageEnglish
Pages (from-to)1765-1767
Number of pages2
JournalChemical Communications (London)
Volume2008
Issue number15
DOIs
Publication statusPublished - 21 Apr 2008

Keywords

  • crystal structures
  • silica
  • condensation
  • silicatein –cathepsin L chimeras
  • pharmacology
  • chemistry

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