Cover Feature: Structural and Kinetic Profiling of Allosteric Modulation of Duplex DNA Induced by DNA-Binding Polyamide Analogues (Chem. Eur. J. 11/2019)

Khalid Aman, Giacomo Padroni, John A. Parkinson, Thomas Welte, Glenn A. Burley

Research output: Contribution to journalEditorialpeer-review

Abstract

DNA-binding polyamides are molecules that hold great promise as regulators of gene expression. One of the challenges in their therapeutic development is understanding the molecular determinants governing their DNA-binding profile. This article describes a new biophysical technique (switchSENSE®) to determine the DNA-binding parameters of polyamide analogues. NMR structural analysis shows that steric bulk distal to the DNA-binding face plays an influential role in allosteric modulation of the DNA duplex. More information can be found in the Full Paper by T. Welte, G. A. Burley et al. on page 2757.

Original languageEnglish
Pages (from-to)2646-2646
Number of pages1
JournalChemistry - A European Journal
Volume25
Issue number11
Early online date28 Jan 2019
DOIs
Publication statusPublished - 21 Feb 2019

Keywords

  • allosterism
  • binding kinetics
  • minor groove binder
  • NMR characterisation
  • pyrrole-imidazole polyamide

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