Abstract
DNA-binding polyamides are molecules that hold great promise as regulators of gene expression. One of the challenges in their therapeutic development is understanding the molecular determinants governing their DNA-binding profile. This article describes a new biophysical technique (switchSENSE®) to determine the DNA-binding parameters of polyamide analogues. NMR structural analysis shows that steric bulk distal to the DNA-binding face plays an influential role in allosteric modulation of the DNA duplex. More information can be found in the Full Paper by T. Welte, G. A. Burley et al. on page 2757.
Original language | English |
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Pages (from-to) | 2646-2646 |
Number of pages | 1 |
Journal | Chemistry - A European Journal |
Volume | 25 |
Issue number | 11 |
Early online date | 28 Jan 2019 |
DOIs | |
Publication status | Published - 21 Feb 2019 |
Keywords
- allosterism
- binding kinetics
- minor groove binder
- NMR characterisation
- pyrrole-imidazole polyamide