Corynebacterium diphtheriae is the etiological agent of diphtheria; an acute toxin-mediated infection of the upper respiratory tract and skin. The toxin gene is encoded on a temperate bacteriophage, which during lysogeny is capable of toxin production. In this chapter, we will summarise current knowledge regarding corynephage, focusing on the lifecycle and biology of the toxin-carrying corynephages that are known to convert pathogenic corynebacteria, and discuss the insights recent genome corynebacterial sequencing has given us.
|Title of host publication||Corynebacterium diphtheriae and Related Toxigenic Species|
|Subtitle of host publication||Genomics, Pathogenicity and Applications|
|Number of pages||15|
|ISBN (Print)||9400776233, 9789400776234|
|Publication status||Published - 1 Aug 2014|
- phage conversion