Corynephages: Infections of the Infectors

Vartul Sangal, Paul A. Hoskisson

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Citations (Scopus)

Abstract

Corynebacterium diphtheriae is the etiological agent of diphtheria; an acute toxin-mediated infection of the upper respiratory tract and skin. The toxin gene is encoded on a temperate bacteriophage, which during lysogeny is capable of toxin production. In this chapter, we will summarise current knowledge regarding corynephage, focusing on the lifecycle and biology of the toxin-carrying corynephages that are known to convert pathogenic corynebacteria, and discuss the insights recent genome corynebacterial sequencing has given us.

Original languageEnglish
Title of host publicationCorynebacterium diphtheriae and Related Toxigenic Species
Subtitle of host publicationGenomics, Pathogenicity and Applications
PublisherSpringer Netherlands
Pages67-81
Number of pages15
ISBN (Electronic)9789400776241
ISBN (Print)9400776233, 9789400776234
DOIs
Publication statusPublished - 1 Aug 2014

Keywords

  • bacteriophage
  • Corynebacterium
  • Corynephage
  • Diphtheria
  • pathogenicity
  • phage conversion
  • toxigenic
  • toxin

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