Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials

Yossi Mandel, Georges Goetz, Daniel Lavinsky, Philip Huie, Keith Mathieson, Lele Wang, Theodore Kamins, Ludwig Galambos, Richard Manivanh, James Harris, Daniel Palanker

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We have previously developed a wireless photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. Here we report that implants having pixel sizes of 280, 140 and 70 μm implanted in the subretinal space in rats with normal and degenerate retina elicit robust cortical responses upon stimulation with pulsed near-IR light. Implant-induced eVEP has shorter latency than visible light-induced VEP, its amplitude increases with peak irradiance and pulse duration, and decreases with frequency in the range of 2-20 Hz, similar to the visible light response. Modular design of the arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.
LanguageEnglish
Article number1980
Number of pages9
JournalNature Communications
Volume4
DOIs
Publication statusPublished - 18 Jun 2013

Fingerprint

Bioelectric potentials
Prosthetics
Evoked Potentials
Prostheses and Implants
Pixels
Light
retina
Infrared radiation
pixels
Electric currents
Retina
Visual Prosthesis
Restoration
Neurons
Scalability
Rats
Retinal Neurons
Retinal Diseases
Cameras
visual perception

Keywords

  • neuroscience
  • photonics
  • retinal prosthesis
  • cortical responses

Cite this

Mandel, Yossi ; Goetz, Georges ; Lavinsky, Daniel ; Huie, Philip ; Mathieson, Keith ; Wang, Lele ; Kamins, Theodore ; Galambos, Ludwig ; Manivanh, Richard ; Harris, James ; Palanker, Daniel. / Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials. In: Nature Communications. 2013 ; Vol. 4.
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abstract = "We have previously developed a wireless photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. Here we report that implants having pixel sizes of 280, 140 and 70 μm implanted in the subretinal space in rats with normal and degenerate retina elicit robust cortical responses upon stimulation with pulsed near-IR light. Implant-induced eVEP has shorter latency than visible light-induced VEP, its amplitude increases with peak irradiance and pulse duration, and decreases with frequency in the range of 2-20 Hz, similar to the visible light response. Modular design of the arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.",
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Mandel, Y, Goetz, G, Lavinsky, D, Huie, P, Mathieson, K, Wang, L, Kamins, T, Galambos, L, Manivanh, R, Harris, J & Palanker, D 2013, 'Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials' Nature Communications, vol. 4, 1980. https://doi.org/10.1038/ncomms2980

Cortical responses elicited by photovoltaic subretinal prostheses exhibit similarities to visually evoked potentials. / Mandel, Yossi; Goetz, Georges; Lavinsky, Daniel; Huie, Philip; Mathieson, Keith; Wang, Lele; Kamins, Theodore; Galambos, Ludwig; Manivanh, Richard; Harris, James; Palanker, Daniel.

In: Nature Communications, Vol. 4, 1980, 18.06.2013.

Research output: Contribution to journalArticle

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AU - Wang, Lele

AU - Kamins, Theodore

AU - Galambos, Ludwig

AU - Manivanh, Richard

AU - Harris, James

AU - Palanker, Daniel

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