Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples

Alberto Moral; Alan Corrigan; F. Borrull; Peter A. G. Cormack; N. Fontanals; R. M. Marcé

doi:10.1016/j.sampre.2024.100136

Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples

Alberto Moral, Alan Corrigan, F. Borrull, Peter A. G. Cormack^*, N. Fontanals^*, R. M. Marcé

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Special issue › peer-review

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Abstract

The application of core-shell materials as packing materials for liquid chromatography columns is common in analytical chemistry, however their use as sorbents in solid-phase extraction (SPE) is surprisingly underexplored. In the present study, core-shell polymer microspheres with strong cation-exchange character were designed and synthesized. These new materials benefit from having hypercrosslinked and relatively thin functional shells, which raises the specific surface areas and sorption capacities of the sorbents and allows for relatively shorter diffusion path lengths for analytes.

The core-shell polymer microspheres were evaluated as SPE sorbents for the extraction of basic pharmaceuticals from environmental water samples. Following optimization of the pH and volume of the loading solution, as well as optimization of the loading step, the SPE method was validated in terms of apparent and relative recoveries, matrix effect, limits of detection and quantification and precision. The method yielded very promising results in terms of apparent recoveries (>39%) and matrix effect (<±29%) and was applied successfully to the determination of basic pharmaceuticals in environmental water samples (river water, effluent wastewater and influent wastewater).

Original language	English
Article number	100136
Journal	Advances in Sample Preparation
Volume	12
Early online date	14 Nov 2024
DOIs	https://doi.org/10.1016/j.sampre.2024.100136
Publication status	E-pub ahead of print - 14 Nov 2024

Funding

These results are part of project PID2020-114587GB-I00 funded by MICIU/AEI/10.13039/501100011033. A. Moral would also like to thank Universitat Rovira i Virgili (URV) for his PhD grant (2020PMF-PIPF-33). A. Corrigan would like to thank the University of Strathclyde and the Engineering and Physical Sciences Research Council (EPSRC) for his Student Excellence Award funded through the Strathclyde Research Studentship Scheme.

Keywords

core-shell polymer microspheres
environmental water samples
pharmaceuticals
polymer-based sorbent
strong cation-exchange interactions

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10.1016/j.sampre.2024.100136Licence: CC BY-NC-ND 4.0

Moral-etal-Core-shell-polymer-microspheres-with-strong-cation-exchange-character-for-the-extraction-of-basic-pharmaceuticals-from-aqueous-samples
For the purposes of open access, a CC BY 4.0 licence has been applied to the accepted manuscript
Accepted author manuscript, 430 KBLicence: CC BY 4.0

Cite this

@article{496f66eaec074da49257573ae54c2747,

title = "Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples",

abstract = "The application of core-shell materials as packing materials for liquid chromatography columns is common in analytical chemistry, however their use as sorbents in solid-phase extraction (SPE) is surprisingly underexplored. In the present study, core-shell polymer microspheres with strong cation-exchange character were designed and synthesized. These new materials benefit from having hypercrosslinked and relatively thin functional shells, which raises the specific surface areas and sorption capacities of the sorbents and allows for relatively shorter diffusion path lengths for analytes.The core-shell polymer microspheres were evaluated as SPE sorbents for the extraction of basic pharmaceuticals from environmental water samples. Following optimization of the pH and volume of the loading solution, as well as optimization of the loading step, the SPE method was validated in terms of apparent and relative recoveries, matrix effect, limits of detection and quantification and precision. The method yielded very promising results in terms of apparent recoveries (>39%) and matrix effect (<±29%) and was applied successfully to the determination of basic pharmaceuticals in environmental water samples (river water, effluent wastewater and influent wastewater).",

keywords = "core-shell polymer microspheres, environmental water samples, pharmaceuticals, polymer-based sorbent, strong cation-exchange interactions",

author = "Alberto Moral and Alan Corrigan and F. Borrull and Cormack, {Peter A. G.} and N. Fontanals and Marc{\'e}, {R. M.}",

note = "For the purposes of open access, a CC BY 4.0 licence has been applied to the accepted manuscript",

year = "2024",

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doi = "10.1016/j.sampre.2024.100136",

language = "English",

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TY - JOUR

T1 - Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples

AU - Moral, Alberto

AU - Corrigan, Alan

AU - Borrull, F.

AU - Cormack, Peter A. G.

AU - Fontanals, N.

AU - Marcé, R. M.

N1 - For the purposes of open access, a CC BY 4.0 licence has been applied to the accepted manuscript

PY - 2024/11/14

Y1 - 2024/11/14

N2 - The application of core-shell materials as packing materials for liquid chromatography columns is common in analytical chemistry, however their use as sorbents in solid-phase extraction (SPE) is surprisingly underexplored. In the present study, core-shell polymer microspheres with strong cation-exchange character were designed and synthesized. These new materials benefit from having hypercrosslinked and relatively thin functional shells, which raises the specific surface areas and sorption capacities of the sorbents and allows for relatively shorter diffusion path lengths for analytes.The core-shell polymer microspheres were evaluated as SPE sorbents for the extraction of basic pharmaceuticals from environmental water samples. Following optimization of the pH and volume of the loading solution, as well as optimization of the loading step, the SPE method was validated in terms of apparent and relative recoveries, matrix effect, limits of detection and quantification and precision. The method yielded very promising results in terms of apparent recoveries (>39%) and matrix effect (<±29%) and was applied successfully to the determination of basic pharmaceuticals in environmental water samples (river water, effluent wastewater and influent wastewater).

AB - The application of core-shell materials as packing materials for liquid chromatography columns is common in analytical chemistry, however their use as sorbents in solid-phase extraction (SPE) is surprisingly underexplored. In the present study, core-shell polymer microspheres with strong cation-exchange character were designed and synthesized. These new materials benefit from having hypercrosslinked and relatively thin functional shells, which raises the specific surface areas and sorption capacities of the sorbents and allows for relatively shorter diffusion path lengths for analytes.The core-shell polymer microspheres were evaluated as SPE sorbents for the extraction of basic pharmaceuticals from environmental water samples. Following optimization of the pH and volume of the loading solution, as well as optimization of the loading step, the SPE method was validated in terms of apparent and relative recoveries, matrix effect, limits of detection and quantification and precision. The method yielded very promising results in terms of apparent recoveries (>39%) and matrix effect (<±29%) and was applied successfully to the determination of basic pharmaceuticals in environmental water samples (river water, effluent wastewater and influent wastewater).

KW - core-shell polymer microspheres

KW - environmental water samples

KW - pharmaceuticals

KW - polymer-based sorbent

KW - strong cation-exchange interactions

UR - https://doi.org/10.17868/strath.00091184

U2 - 10.1016/j.sampre.2024.100136

DO - 10.1016/j.sampre.2024.100136

M3 - Special issue

SN - 2772-5820

VL - 12

JO - Advances in Sample Preparation

JF - Advances in Sample Preparation

M1 - 100136

ER -

Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples

Abstract

Funding

Keywords

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DTP 2224 University of Strathclyde | Corrigan, Alan

Cite this

Core-shell polymer microspheres with strong cation-exchange character for the extraction of basic pharmaceuticals from aqueous samples

Abstract

Funding

Keywords

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Other files and links

Fingerprint

Projects

DTP 2224 University of Strathclyde | Corrigan, Alan

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