Core outcome measures for exercise studies in people with multiple sclerosis: recommendations from a multidisciplinary consensus meeting

Lorna Paul, Susan Coote, Jean Crosbie, Diane Dixon, Leigh Hale, Ed Holloway, Paul McCrone, Linda Miller, John Saxton, Caroline Sincock, Lesley White

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Evidence shows that exercise is beneficial for people with multiple sclerosis (MS); however, statistical pooling of data is difficult because of the diversity of outcome measures used. The objective of this review is to report the recommendations of an International Consensus Meeting for a core set of outcome measures for use in exercise studies in MS. From the 100 categories of the International Classification of Function Core Sets for MS, 57 categories were considered as likely/potentially likely to be affected by exercise and were clustered into seven core groups. Outcome measures to address each group were evaluated regarding, for example, psychometric properties. The following are recommended: Modified Fatigue Impact Scale (MFIS) or Fatigue Severity Scale (FSS) for energy and drive, 6-Minute Walk Test (6MWT) for exercise tolerance, Timed Up and Go (TUG) for muscle function and moving around, Multiple Sclerosis Impact Scale (MSIS-29) or Multiple Sclerosis Quality of Life-54 Instrument (MSQoL54) for quality of life and body mass index (BMI) or waist-hip ratio (WHR) for the health risks associated with excess body fat. A cost effectiveness analysis and qualitative evaluation should be included where possible. Using these core measures ensures that future meta-analyses of exercise studies in MS are more robust and thus more effectively inform practice.

LanguageEnglish
Pages1641-1650
Number of pages10
JournalMultiple Sclerosis Journal
Volume20
Issue number12
Early online date17 Mar 2014
DOIs
Publication statusPublished - Oct 2014

Fingerprint

Multiple Sclerosis
Consensus
Outcome Assessment (Health Care)
Fatigue
Meta-Analysis
Quality of Life
Exercise Tolerance
Waist-Hip Ratio
Psychometrics
Cost-Benefit Analysis
Adipose Tissue
Body Mass Index
Muscles
Health

Keywords

  • multiple sclerosis
  • outcome measures
  • exercise

Cite this

Paul, Lorna ; Coote, Susan ; Crosbie, Jean ; Dixon, Diane ; Hale, Leigh ; Holloway, Ed ; McCrone, Paul ; Miller, Linda ; Saxton, John ; Sincock, Caroline ; White, Lesley. / Core outcome measures for exercise studies in people with multiple sclerosis : recommendations from a multidisciplinary consensus meeting. In: Multiple Sclerosis Journal. 2014 ; Vol. 20, No. 12. pp. 1641-1650.
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Paul, L, Coote, S, Crosbie, J, Dixon, D, Hale, L, Holloway, E, McCrone, P, Miller, L, Saxton, J, Sincock, C & White, L 2014, 'Core outcome measures for exercise studies in people with multiple sclerosis: recommendations from a multidisciplinary consensus meeting' Multiple Sclerosis Journal, vol. 20, no. 12, pp. 1641-1650. https://doi.org/10.1177/1352458514526944

Core outcome measures for exercise studies in people with multiple sclerosis : recommendations from a multidisciplinary consensus meeting. / Paul, Lorna; Coote, Susan; Crosbie, Jean; Dixon, Diane; Hale, Leigh; Holloway, Ed; McCrone, Paul; Miller, Linda; Saxton, John; Sincock, Caroline; White, Lesley.

In: Multiple Sclerosis Journal, Vol. 20, No. 12, 10.2014, p. 1641-1650.

Research output: Contribution to journalArticle

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