Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides

David Lindsay, Wolfgang Dohle, Paul Knochel

Research output: Contribution to journalArticlepeer-review

80 Citations (Scopus)

Abstract

Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.
Original languageEnglish
Pages (from-to)2871-2873
Number of pages3
JournalOrganic Letters
Volume3
Issue number18
DOIs
Publication statusPublished - 4 Aug 2001

Keywords

  • arylmagnesium reagents
  • arylmagnesium halides
  • alkyl iodides
  • benzylic bromide

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