Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides

David Lindsay; Wolfgang Dohle; Paul Knochel

doi:10.1021/ol0163272

Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides

David Lindsay, Wolfgang Dohle, Paul Knochel

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.

Original language	English
Pages (from-to)	2871-2873
Number of pages	3
Journal	Organic Letters
Volume	3
Issue number	18
DOIs	https://doi.org/10.1021/ol0163272
Publication status	Published - 4 Aug 2001

Keywords

arylmagnesium reagents
arylmagnesium halides
alkyl iodides
benzylic bromide

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10.1021/ol0163272

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title = "Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides",

abstract = "Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.",

keywords = "arylmagnesium reagents, arylmagnesium halides, alkyl iodides, benzylic bromide",

author = "David Lindsay and Wolfgang Dohle and Paul Knochel",

year = "2001",

month = aug,

day = "4",

doi = "10.1021/ol0163272",

language = "English",

volume = "3",

pages = "2871--2873",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "18",

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TY - JOUR

T1 - Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides

AU - Lindsay, David

AU - Dohle, Wolfgang

AU - Knochel, Paul

PY - 2001/8/4

Y1 - 2001/8/4

N2 - Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.

AB - Functionalized arylmagnesium halides, prepared via an iodine−magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN·2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.

KW - arylmagnesium reagents

KW - arylmagnesium halides

KW - alkyl iodides

KW - benzylic bromide

U2 - 10.1021/ol0163272

DO - 10.1021/ol0163272

M3 - Article

VL - 3

SP - 2871

EP - 2873

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 18

ER -