Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar, Rebecca J. Sowden, Katherine D. Trotter, Michelle K. Taylor, David Smith, Alan R. Kennedy, John Reglinski, Corinne M. Spickett

Research output: Contribution to journalArticle

7 Citations (Scopus)
11 Downloads (Pure)

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Original languageEnglish
Pages (from-to)903-912
Number of pages10
JournalBioMetals
Volume28
DOIs
Publication statusPublished - 9 Aug 2015

Keywords

  • copper macrocycles
  • imaging
  • inflammation
  • oxidation–reduction
  • redox sensitive contrast agent

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