An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines, e.g., I, were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
- aryl iodides
- copper-catalyzed N-arylation
- aryl coupling partners
Jones, K. L., Porzelle, A., Hall, A., Woodrow, M. D., & Tomkinson, N. C. O. (2008). Copper-catalyzed coupling of hydroxylamines with aryl iodides. Organic Letters, 10(5), 797-800. https://doi.org/10.1021/ol7029273