Copper-catalyzed coupling of hydroxylamines with aryl iodides.

Kerri L. Jones, Achim Porzelle, Adrian Hall, Michael D. Woodrow, Nicholas C. O. Tomkinson

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines, e.g., I, were transformed in good to excellent yield with a broad range of aryl coupling partners. Methods for the selective deprotection of either the N- or O-substituents for further functionalization are also described.
Original languageEnglish
Pages (from-to)797-800
Number of pages4
JournalOrganic Letters
Issue number5
Early online date26 Jan 2008
Publication statusPublished - 2008


  • aryl iodides
  • copper-catalyzed N-arylation
  • aryl coupling partners


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