Coordination of eye and head movements during smooth pursuit in patients with vestibular failure

J A Waterston, G R Barnes, M A Grealy, L M Luxon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

During pursuit of smoothly moving targets with combined eye and head movements in normal subjects, accurate gaze control depends on successful interaction of the vestibular and head movement signals with the ocular pursuit mechanisms. To investigate compensation for loss of the vestibulo-ocular reflex during head-free pursuit in labyrinthine-deficient patients, pursuit performance was assessed and compared under head-fixed and head-free conditions in five patients with isolated bilateral loss of vestibular function. Target motion consisted of predictable and unpredictable pseudo-random waveforms containing the sum of three or four sinusoids. Comparison of slow-phase gaze velocity gains under head-free and head-fixed conditions revealed no significant differences during pursuit of any of the three pseudo-random waveforms. The finding of significant compensatory eye movement during active head movements in darkness in labyrinthine-deficient patients, which were comparable in character and gain to the vestibular eye movement elicited in normal subjects, probably explains the similarity of the head-fixed and head-free responses. In two additional patients with cerebellar degeneration and vestibular failure, no compensatory eye movement response was observed, implying that the cerebellum is necessary for the generation of such responses in labyrinthine-deficient patients.
LanguageEnglish
Pages1125-1131
Number of pages7
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume55
Issue number12
DOIs
Publication statusPublished - Dec 1992

Fingerprint

Smooth Pursuit
Head Movements
Eye Movements
Head
Vestibulo-Ocular Reflex
Darkness
Head Movement
Pursuit
Cerebellum

Keywords

  • adult
  • attention
  • dark adaptation
  • dominance cerebral
  • female
  • humans
  • labyrinth diseases
  • male
  • microcomputers
  • middle aged
  • pursuit
  • vestibulo-ocular
  • signal processing
  • spinocerebellar degenerations
  • vestibular function tests
  • coordination
  • eye and head movements
  • smooth pursuit
  • patients
  • vestibular failure

Cite this

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title = "Coordination of eye and head movements during smooth pursuit in patients with vestibular failure",
abstract = "During pursuit of smoothly moving targets with combined eye and head movements in normal subjects, accurate gaze control depends on successful interaction of the vestibular and head movement signals with the ocular pursuit mechanisms. To investigate compensation for loss of the vestibulo-ocular reflex during head-free pursuit in labyrinthine-deficient patients, pursuit performance was assessed and compared under head-fixed and head-free conditions in five patients with isolated bilateral loss of vestibular function. Target motion consisted of predictable and unpredictable pseudo-random waveforms containing the sum of three or four sinusoids. Comparison of slow-phase gaze velocity gains under head-free and head-fixed conditions revealed no significant differences during pursuit of any of the three pseudo-random waveforms. The finding of significant compensatory eye movement during active head movements in darkness in labyrinthine-deficient patients, which were comparable in character and gain to the vestibular eye movement elicited in normal subjects, probably explains the similarity of the head-fixed and head-free responses. In two additional patients with cerebellar degeneration and vestibular failure, no compensatory eye movement response was observed, implying that the cerebellum is necessary for the generation of such responses in labyrinthine-deficient patients.",
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author = "Waterston, {J A} and Barnes, {G R} and Grealy, {M A} and Luxon, {L M}",
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Coordination of eye and head movements during smooth pursuit in patients with vestibular failure. / Waterston, J A; Barnes, G R; Grealy, M A; Luxon, L M.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 55, No. 12, 12.1992, p. 1125-1131.

Research output: Contribution to journalArticle

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AB - During pursuit of smoothly moving targets with combined eye and head movements in normal subjects, accurate gaze control depends on successful interaction of the vestibular and head movement signals with the ocular pursuit mechanisms. To investigate compensation for loss of the vestibulo-ocular reflex during head-free pursuit in labyrinthine-deficient patients, pursuit performance was assessed and compared under head-fixed and head-free conditions in five patients with isolated bilateral loss of vestibular function. Target motion consisted of predictable and unpredictable pseudo-random waveforms containing the sum of three or four sinusoids. Comparison of slow-phase gaze velocity gains under head-free and head-fixed conditions revealed no significant differences during pursuit of any of the three pseudo-random waveforms. The finding of significant compensatory eye movement during active head movements in darkness in labyrinthine-deficient patients, which were comparable in character and gain to the vestibular eye movement elicited in normal subjects, probably explains the similarity of the head-fixed and head-free responses. In two additional patients with cerebellar degeneration and vestibular failure, no compensatory eye movement response was observed, implying that the cerebellum is necessary for the generation of such responses in labyrinthine-deficient patients.

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