Cooperative, ion-sensitive co-assembly of tripeptide hydrogels

Yousef M. Abul-Haija, Gary G. Scott, Jugal Kishore Sahoo, Tell Tuttle, Rein V. Ulijn

Research output: Contribution to journalArticle

19 Citations (Scopus)
34 Downloads (Pure)

Abstract

Peptide co-assembly is of interest for the development of functional supramolecular biomaterials. Herein, computational simulations were combined with experimental validation to aid the design and understanding of cooporative co-assembly of a
structure-forming tripeptide (FFD) and a functional copper-binding tripeptide (GHK) leading to hydrogel formation in response to complexation with copper ions.
Original languageEnglish
Pages (from-to)9562-9565
Number of pages4
JournalChemical Communications
Early online date7 Aug 2017
DOIs
Publication statusE-pub ahead of print - 7 Aug 2017

Keywords

  • peptide co-assembly
  • functional supramolecular biomaterials
  • computational simulations
  • structure-forming tripeptide
  • copper-binding tripeptide
  • FFD
  • GHK
  • hydrogel formation
  • copper ions

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