Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

A Christoforou; K A McGhee; S W Morris; P A Thomson; A McLean; H S Torrance; S Le Hellard; B S Pickard; D StClair; W J Muir; D H Blackwood; D J Porteous; K L Evans

doi:10.1038/mp.2010.25

Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

A Christoforou, K A McGhee, S W Morris, P A Thomson, A McLean, H S Torrance, S Le Hellard, B S Pickard, D StClair, W J Muir, D H Blackwood, D J Porteous, K L Evans

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Several strong candidate genes and regions have been implicated in bipolar disorder (BP) and schizophrenia (SCZ) through linkage and association studies. These disorders have also recently been studied in genome-wide association studies (GWAS), identifying further putative candidate loci, albeit with lower levels of significance and reproducibility than in GWAS of other complex disorders.

Original language	English
Pages (from-to)	240-242
Number of pages	3
Journal	Molecular Psychiatry
Volume	16
Issue number	3
DOIs	https://doi.org/10.1038/mp.2010.25
Publication status	Published - Mar 2011

Keywords

bipolar disorder
chromosome mapping
Pair 4
genetic linkage
genome-wide association study
humans
phenotype
polymorphism, single nucleotide
receptors, cell surface
schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/mp.2010.25

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Christoforou, A., McGhee, K. A., Morris, S. W., Thomson, P. A., McLean, A., Torrance, H. S., Le Hellard, S., Pickard, B. S., StClair, D., Muir, W. J., Blackwood, D. H., Porteous, D. J., & Evans, K. L. (2011). Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p. Molecular Psychiatry, 16(3), 240-242. https://doi.org/10.1038/mp.2010.25

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abstract = "Several strong candidate genes and regions have been implicated in bipolar disorder (BP) and schizophrenia (SCZ) through linkage and association studies. These disorders have also recently been studied in genome-wide association studies (GWAS), identifying further putative candidate loci, albeit with lower levels of significance and reproducibility than in GWAS of other complex disorders.",

keywords = "bipolar disorder, chromosome mapping, Pair 4, genetic linkage , genome-wide association study, humans, phenotype, polymorphism, single nucleotide, receptors, cell surface, schizophrenia",

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Christoforou, A, McGhee, KA, Morris, SW, Thomson, PA, McLean, A, Torrance, HS, Le Hellard, S, Pickard, BS, StClair, D, Muir, WJ, Blackwood, DH, Porteous, DJ & Evans, KL 2011, 'Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p', Molecular Psychiatry, vol. 16, no. 3, pp. 240-242. https://doi.org/10.1038/mp.2010.25

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T1 - Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

AU - Christoforou, A

AU - McGhee, K A

AU - Morris, S W

AU - Thomson, P A

AU - McLean, A

AU - Torrance, H S

AU - Le Hellard, S

AU - Pickard, B S

AU - StClair, D

AU - Muir, W J

AU - Blackwood, D H

AU - Porteous, D J

AU - Evans, K L

PY - 2011/3

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AB - Several strong candidate genes and regions have been implicated in bipolar disorder (BP) and schizophrenia (SCZ) through linkage and association studies. These disorders have also recently been studied in genome-wide association studies (GWAS), identifying further putative candidate loci, albeit with lower levels of significance and reproducibility than in GWAS of other complex disorders.

KW - bipolar disorder

KW - chromosome mapping

KW - Pair 4

KW - genetic linkage

KW - genome-wide association study

KW - humans

KW - phenotype

KW - polymorphism, single nucleotide

KW - receptors, cell surface

KW - schizophrenia

UR - http://www.nature.com/mp/

U2 - 10.1038/mp.2010.25

DO - 10.1038/mp.2010.25

M3 - Article

C2 - 20351716

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JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 3

ER -

Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

Abstract

Keywords

UN SDGs

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