Convergence of linkage, association and GWAS findings for a candidate region for bipolar disorder and schizophrenia on chromosome 4p

A Christoforou, K A McGhee, S W Morris, P A Thomson, A McLean, H S Torrance, S Le Hellard, B S Pickard, D StClair, W J Muir, D H Blackwood, D J Porteous, K L Evans

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28 Citations (Scopus)

Abstract

Several strong candidate genes and regions have been implicated in bipolar disorder (BP) and schizophrenia (SCZ) through linkage and association studies. These disorders have also recently been studied in genome-wide association studies (GWAS), identifying further putative candidate loci, albeit with lower levels of significance and reproducibility than in GWAS of other complex disorders.
Original languageEnglish
Pages (from-to)240-242
Number of pages3
JournalMolecular Psychiatry
Volume16
Issue number3
DOIs
Publication statusPublished - Mar 2011

Keywords

  • bipolar disorder
  • chromosome mapping
  • Pair 4
  • genetic linkage
  • genome-wide association study
  • humans
  • phenotype
  • polymorphism, single nucleotide
  • receptors, cell surface
  • schizophrenia

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