Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy

P L Calderon-Gonzalez, Mario A. Parra Rodriguez, W Rodriguez-Martinez, Z Lestayo-O'Farrill, J Gutierrez-Gil, Y Montejo-Pujadas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction. Steinert's myotonic dystrophy (SMD) is a systemic-type dominant autosomal disease, with variable clinical expression. Recent magnetic resonance studies conducted in patients with this disease have described the presence of lesions in the white matter of the brain and there have also been reports of a correlation between these and the presence of cognitive disorders. Nevertheless, very little work has been published about the electroencephalographic (EEG) findings in this disease. Patients and methods. In this study both conventional and quantitative EEG were performed on 10 patients with SMD aged between 17 and 50 years. Results. 90% of the patients showed a posterior alpha rhythm that was disorganised but which reacted on opening and closing the eyes, as well as the presence of continuous theta activity over the base activity that was bilaterally more pronounced towards the frontal-central regions. In the quantitative analysis we observed an increase in the absolute energies for the slow bands and a decrease for the fast bands on the frequency spectrum. In most patients (80%) spectral peaks were found within the theta range of frequencies as a correlate of the slow activity observed in the conventional analysis. Conclusions. It can be concluded that a quantitative EEG could be useful in the study of what, for many years, has been considered to be a 'neuromuscular' disease and that the use of other more precise methods, such as cerebral coherence and brain electrical tomography, could shed new light on the functional management of these patients.
LanguageEnglish
Pages12-17
Number of pages6
JournalRevista de neurologia
Volume39
Issue number1
Publication statusPublished - 1 Jul 2004

Fingerprint

Myotonic Dystrophy
Electroencephalography
Alpha Rhythm
Neuromuscular Diseases
Brain
Magnetic Resonance Spectroscopy
Tomography

Keywords

  • electroencephalography
  • Steinert's myotonic dystrophy
  • quantitative EEG

Cite this

Calderon-Gonzalez, P. L., Parra Rodriguez, M. A., Rodriguez-Martinez, W., Lestayo-O'Farrill, Z., Gutierrez-Gil, J., & Montejo-Pujadas, Y. (2004). Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy. 39(1), 12-17.
Calderon-Gonzalez, P L ; Parra Rodriguez, Mario A. ; Rodriguez-Martinez, W ; Lestayo-O'Farrill, Z ; Gutierrez-Gil, J ; Montejo-Pujadas, Y. / Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy. 2004 ; Vol. 39, No. 1. pp. 12-17.
@article{e3809e6e846048bba92682143718a05e,
title = "Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy",
abstract = "Introduction. Steinert's myotonic dystrophy (SMD) is a systemic-type dominant autosomal disease, with variable clinical expression. Recent magnetic resonance studies conducted in patients with this disease have described the presence of lesions in the white matter of the brain and there have also been reports of a correlation between these and the presence of cognitive disorders. Nevertheless, very little work has been published about the electroencephalographic (EEG) findings in this disease. Patients and methods. In this study both conventional and quantitative EEG were performed on 10 patients with SMD aged between 17 and 50 years. Results. 90{\%} of the patients showed a posterior alpha rhythm that was disorganised but which reacted on opening and closing the eyes, as well as the presence of continuous theta activity over the base activity that was bilaterally more pronounced towards the frontal-central regions. In the quantitative analysis we observed an increase in the absolute energies for the slow bands and a decrease for the fast bands on the frequency spectrum. In most patients (80{\%}) spectral peaks were found within the theta range of frequencies as a correlate of the slow activity observed in the conventional analysis. Conclusions. It can be concluded that a quantitative EEG could be useful in the study of what, for many years, has been considered to be a 'neuromuscular' disease and that the use of other more precise methods, such as cerebral coherence and brain electrical tomography, could shed new light on the functional management of these patients.",
keywords = "electroencephalography, Steinert's myotonic dystrophy, quantitative EEG",
author = "Calderon-Gonzalez, {P L} and {Parra Rodriguez}, {Mario A.} and W Rodriguez-Martinez and Z Lestayo-O'Farrill and J Gutierrez-Gil and Y Montejo-Pujadas",
year = "2004",
month = "7",
day = "1",
language = "English",
volume = "39",
pages = "12--17",
number = "1",

}

Calderon-Gonzalez, PL, Parra Rodriguez, MA, Rodriguez-Martinez, W, Lestayo-O'Farrill, Z, Gutierrez-Gil, J & Montejo-Pujadas, Y 2004, 'Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy' vol. 39, no. 1, pp. 12-17.

Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy. / Calderon-Gonzalez, P L; Parra Rodriguez, Mario A.; Rodriguez-Martinez, W; Lestayo-O'Farrill, Z; Gutierrez-Gil, J; Montejo-Pujadas, Y.

Vol. 39, No. 1, 01.07.2004, p. 12-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy

AU - Calderon-Gonzalez, P L

AU - Parra Rodriguez, Mario A.

AU - Rodriguez-Martinez, W

AU - Lestayo-O'Farrill, Z

AU - Gutierrez-Gil, J

AU - Montejo-Pujadas, Y

PY - 2004/7/1

Y1 - 2004/7/1

N2 - Introduction. Steinert's myotonic dystrophy (SMD) is a systemic-type dominant autosomal disease, with variable clinical expression. Recent magnetic resonance studies conducted in patients with this disease have described the presence of lesions in the white matter of the brain and there have also been reports of a correlation between these and the presence of cognitive disorders. Nevertheless, very little work has been published about the electroencephalographic (EEG) findings in this disease. Patients and methods. In this study both conventional and quantitative EEG were performed on 10 patients with SMD aged between 17 and 50 years. Results. 90% of the patients showed a posterior alpha rhythm that was disorganised but which reacted on opening and closing the eyes, as well as the presence of continuous theta activity over the base activity that was bilaterally more pronounced towards the frontal-central regions. In the quantitative analysis we observed an increase in the absolute energies for the slow bands and a decrease for the fast bands on the frequency spectrum. In most patients (80%) spectral peaks were found within the theta range of frequencies as a correlate of the slow activity observed in the conventional analysis. Conclusions. It can be concluded that a quantitative EEG could be useful in the study of what, for many years, has been considered to be a 'neuromuscular' disease and that the use of other more precise methods, such as cerebral coherence and brain electrical tomography, could shed new light on the functional management of these patients.

AB - Introduction. Steinert's myotonic dystrophy (SMD) is a systemic-type dominant autosomal disease, with variable clinical expression. Recent magnetic resonance studies conducted in patients with this disease have described the presence of lesions in the white matter of the brain and there have also been reports of a correlation between these and the presence of cognitive disorders. Nevertheless, very little work has been published about the electroencephalographic (EEG) findings in this disease. Patients and methods. In this study both conventional and quantitative EEG were performed on 10 patients with SMD aged between 17 and 50 years. Results. 90% of the patients showed a posterior alpha rhythm that was disorganised but which reacted on opening and closing the eyes, as well as the presence of continuous theta activity over the base activity that was bilaterally more pronounced towards the frontal-central regions. In the quantitative analysis we observed an increase in the absolute energies for the slow bands and a decrease for the fast bands on the frequency spectrum. In most patients (80%) spectral peaks were found within the theta range of frequencies as a correlate of the slow activity observed in the conventional analysis. Conclusions. It can be concluded that a quantitative EEG could be useful in the study of what, for many years, has been considered to be a 'neuromuscular' disease and that the use of other more precise methods, such as cerebral coherence and brain electrical tomography, could shed new light on the functional management of these patients.

KW - electroencephalography

KW - Steinert's myotonic dystrophy

KW - quantitative EEG

M3 - Article

VL - 39

SP - 12

EP - 17

IS - 1

ER -

Calderon-Gonzalez PL, Parra Rodriguez MA, Rodriguez-Martinez W, Lestayo-O'Farrill Z, Gutierrez-Gil J, Montejo-Pujadas Y. Conventional and quantitative electroencephalography in patients with Steinert's myotonic dystrophy. 2004 Jul 1;39(1):12-17.