Controlling cell morphology using amino acid modified cellulose

Stephen J. Eichhorn, Deepak Kalaskar, Rein Ulijn, Julie E. Gough, Morgan Alexander, David Scurr, William W. Sampson

Research output: Contribution to journalMeeting abstract

Abstract

This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.
Original languageEnglish
JournalAbstracts of papers - American Chemical Society
Volume87
Issue number9
DOIs
Publication statusPublished - 22 Mar 2009
Event237th ACS National Meeting - Salt Lake City, United States
Duration: 22 Mar 200926 Mar 2009

Keywords

  • control
  • cell morphology
  • amino acid
  • modified cellulose

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