Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Lauren R. Agnew, Dyanne L. Cruickshank, Thomas McGlone, Chick C. Wilson

Research output: Contribution to journalArticle

22 Citations (Scopus)
220 Downloads (Pure)

Abstract

A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

Original languageEnglish
Pages (from-to)7368-7371
Number of pages4
JournalChemical Communications
Volume52
Issue number46
Early online date19 Feb 2016
DOIs
Publication statusPublished - 11 Jun 2016

Keywords

  • acetaminophen
  • paracetamol
  • cooling crystallization
  • acetaminophen solubilities

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