TY - JOUR
T1 - Controlled production of the elusive metastable form II of acetaminophen (paracetamol)
T2 - a fully scalable templating approach in a cooling environment
AU - Agnew, Lauren R.
AU - Cruickshank, Dyanne L.
AU - McGlone, Thomas
AU - Wilson, Chick C.
PY - 2016/6/11
Y1 - 2016/6/11
N2 - A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
AB - A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
KW - acetaminophen
KW - paracetamol
KW - cooling crystallization
KW - acetaminophen solubilities
UR - http://www.scopus.com/inward/record.url?scp=84973315123&partnerID=8YFLogxK
UR - http://pubs.rsc.org/en/journals/journalissues/cc
U2 - 10.1039/c6cc01032f
DO - 10.1039/c6cc01032f
M3 - Article
AN - SCOPUS:84973315123
VL - 52
SP - 7368
EP - 7371
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 46
ER -