Abstract
A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
| Original language | English |
|---|---|
| Pages (from-to) | 7368-7371 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue number | 46 |
| Early online date | 19 Feb 2016 |
| DOIs | |
| Publication status | Published - 11 Jun 2016 |
Keywords
- acetaminophen
- paracetamol
- cooling crystallization
- acetaminophen solubilities
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Agnew, L. R., Cruickshank, D. L., McGlone, T., & Wilson, C. C. (2016). Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment. Chemical Communications, 52(46), 7368-7371. https://doi.org/10.1039/c6cc01032f