Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Lauren R. Agnew, Dyanne L. Cruickshank, Thomas McGlone, Chick C. Wilson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

LanguageEnglish
Pages7368-7371
Number of pages4
JournalChemical Communications
Volume52
Issue number46
Early online date19 Feb 2016
DOIs
Publication statusPublished - 11 Jun 2016

Fingerprint

Acetaminophen
Application programming interfaces (API)
Solubility
Crystallization
Cooling

Keywords

  • acetaminophen
  • paracetamol
  • cooling crystallization
  • acetaminophen solubilities

Cite this

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Controlled production of the elusive metastable form II of acetaminophen (paracetamol) : a fully scalable templating approach in a cooling environment. / Agnew, Lauren R.; Cruickshank, Dyanne L.; McGlone, Thomas; Wilson, Chick C.

In: Chemical Communications, Vol. 52, No. 46, 11.06.2016, p. 7368-7371.

Research output: Contribution to journalArticle

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AU - Wilson, Chick C.

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N2 - A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

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