TY - JOUR
T1 - Control of enhanced raman scattering using a DNA-based assembly process of dye-coded nanoparticles
AU - Graham, D.
AU - Thompson, D.G.
AU - Smith, W.E.
AU - Faulds, K.
N1 - http://suprimo.lib.strath.ac.uk/primo_library/libweb/action/display.do?ct=display&doc=SUSFX1000000000239775&indx=1&frbg=&dum=true&vid=SUVU01&vl(54032236UI0)=lsr02&vl(96071691UI1)=all_items&srt=rank&indx=1&dstmp=1271692113117&tab=local&ct=search&scp.scps=scope%3A(SU)&vl(freeText0)=Nature%20nanotechnology&fn=search&mode=Basic&dscnt=0
PY - 2008/9
Y1 - 2008/9
N2 - Enhanced Raman scattering from metal surfaces has been investigated for over 30 years1. Silver surfaces are known to produce a large effect, and this can be maximized by producing a roughened surface, which can be achieved by the aggregation of silver nanoparticles2, 3, 4. However, an approach to control this aggregation, in particular through the interaction of biological molecules such as DNA, has not been reported. Here we show the selective turning on of the surface enhanced resonance Raman scattering5 effect on dye-coded, DNA-functionalized, silver nanoparticles through a target-dependent, sequence-specific DNA hybridization assembly that exploits the electromagnetic enhancement mechanism for the scattering. Dye-coded nanoparticles that do not undergo hybridization experience no enhancement and hence do not give surface enhanced resonance Raman scattering. This is due to the massive difference in enhancement from nanoparticle assemblies compared with individual nanoparticles. The electromagnetic enhancement is the dominant effect and, coupled with an understanding of the surface chemistry, allows surface enhanced resonance Raman scattering nanosensors to be designed based on a natural biological recognition process.
(Abstract copied from: http://www.nature.com/nnano/journal/v3/n9/abs/nnano.2008.189.html)
AB - Enhanced Raman scattering from metal surfaces has been investigated for over 30 years1. Silver surfaces are known to produce a large effect, and this can be maximized by producing a roughened surface, which can be achieved by the aggregation of silver nanoparticles2, 3, 4. However, an approach to control this aggregation, in particular through the interaction of biological molecules such as DNA, has not been reported. Here we show the selective turning on of the surface enhanced resonance Raman scattering5 effect on dye-coded, DNA-functionalized, silver nanoparticles through a target-dependent, sequence-specific DNA hybridization assembly that exploits the electromagnetic enhancement mechanism for the scattering. Dye-coded nanoparticles that do not undergo hybridization experience no enhancement and hence do not give surface enhanced resonance Raman scattering. This is due to the massive difference in enhancement from nanoparticle assemblies compared with individual nanoparticles. The electromagnetic enhancement is the dominant effect and, coupled with an understanding of the surface chemistry, allows surface enhanced resonance Raman scattering nanosensors to be designed based on a natural biological recognition process.
(Abstract copied from: http://www.nature.com/nnano/journal/v3/n9/abs/nnano.2008.189.html)
KW - control
KW - enhanced raman scattering
KW - DNA-based assembly process
KW - dye-coded nanoparticles
U2 - 10.1038/nnano.2008.189
DO - 10.1038/nnano.2008.189
M3 - Article
VL - 3
SP - 548
EP - 551
JO - Nature Nanotechnology
JF - Nature Nanotechnology
SN - 1748-3387
IS - 9
ER -