Abstract
A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.
Original language | English |
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Title of host publication | 2019 IEEE International Ultrasonics Symposium, IUS 2019 |
Place of Publication | Piscataway, N.J. |
Pages | 1077-1080 |
Number of pages | 4 |
ISBN (Electronic) | 9781728145969 |
DOIs | |
Publication status | Published - 9 Dec 2019 |
Event | 2019 IEEE International Ultrasonics Symposium: IEEE UFFC - SECC, Glasgow, United Kingdom Duration: 6 Oct 2019 → 9 Oct 2019 https://attend.ieee.org/ius-2019/ |
Publication series
Name | IEEE International Ultrasonics Symposium, IUS |
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Volume | 2019-October |
ISSN (Print) | 1948-5719 |
ISSN (Electronic) | 1948-5727 |
Conference
Conference | 2019 IEEE International Ultrasonics Symposium |
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Abbreviated title | IUS 2019 |
Country | United Kingdom |
City | Glasgow |
Period | 6/10/19 → 9/10/19 |
Internet address |
Keywords
- colorectal cancer
- contrast-enhanced magneto-motive ultrasound
- elastography
- magnetic microbubbles
- SPION