Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging: assessment of sensitivity and resolution to detect alterations in tissue stiffness

Sandra Sjöstrand, Maria Evertsson, Claire Thring, Marion Bacou, Susan Farrington, Susan Moug, Carmel Moran, Tomas Jansson, Helen Mulvana

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Abstract

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with potential to indicate alterations in tissue stiffness, but it is limited by small vibration amplitudes. We propose CE-MMUS using SPION loaded microbubbles (SPION-MBs) to enhance sensitivity, reduce toxicity, and offer additional diagnostic or perfusion information. Laser doppler vibrometry measurements was performed on SPION containing tissue mimicking material during magnetic excitation. These measurements show a vibration amplitude of 279 ± 113 μm in a material with Young's modulus of 24.3 ± 2.8 kPa, while the displacements were substantially larger, 426 ± 9 μm, in the softer material, with a Young's modulus of 9.6 ± 0.8 kPa. Magnetic field measurement data was used to calibrate finite element modelling of both MMUS and CE-MMUS. SPION-MBs were shown to be capable of inducing larger tissue displacements under a given magnetic field than SPIONs alone, leading to axial displacements of up to 2.3x larger. A doubling in tissue stiffness (as may occur in cancer) reduces the vibration amplitude. Thus, there is potential for CE-MMUS to achieve improved stiffness sensitivity. Our aim is to define the potential contribution of CE-MMUS in colorectal cancer diagnosis and surgical guidance.

Original languageEnglish
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
Place of PublicationPiscataway, N.J.
Pages1077-1080
Number of pages4
ISBN (Electronic)9781728145969
DOIs
Publication statusPublished - 9 Dec 2019
Event2019 IEEE International Ultrasonics Symposium: IEEE UFFC - SECC, Glasgow, United Kingdom
Duration: 6 Oct 20199 Oct 2019
https://attend.ieee.org/ius-2019/

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium
Abbreviated titleIUS 2019
CountryUnited Kingdom
CityGlasgow
Period6/10/199/10/19
Internet address

Keywords

  • colorectal cancer
  • contrast-enhanced magneto-motive ultrasound
  • elastography
  • magnetic microbubbles
  • SPION

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    Sjöstrand, S., Evertsson, M., Thring, C., Bacou, M., Farrington, S., Moug, S., ... Mulvana, H. (2019). Contrast-enhanced magnetomotive ultrasound imaging (CE-MMUS) for colorectal cancer staging: assessment of sensitivity and resolution to detect alterations in tissue stiffness. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 1077-1080). (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). Piscataway, N.J.. https://doi.org/10.1109/ULTSYM.2019.8926058