Continuous pharmaceutical crystallization from solution

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The pharmaceutical industry has traditionally employed exclusively batch manufacturing for drug substances. The current trend is to explore continuous manufacturing; this chapter described the process by which a continuous pharmaceutical crystallization can be developed.
Original languageEnglish
Title of host publicationEngineering Crystallography
Subtitle of host publicationFrom Molecule to Crystal to Functional Form
EditorsKevin J. Roberts, Robert Docherty, Rui Tamura
Place of PublicationDordrecht, The Netherlands
PublisherSpringer
Chapter19
Pages315-329
Number of pages15
Edition1st
ISBN (Print)9789402411157, 9789402411188, 9789402411171
DOIs
Publication statusPublished - 28 Jul 2017
EventNATO Advanced Study Institute on Molecules to Crystals to Powders: Understanding Structure Versus Function - Erice, Sicily, Italy
Duration: 4 Jun 201514 Jun 2015

Course

CourseNATO Advanced Study Institute on Molecules to Crystals to Powders
CountryItaly
CitySicily
Period4/06/1514/06/15

Keywords

  • continuous crystallization
  • pharmaceutical crystallization
  • process development
  • nucleation
  • growth
  • purification
  • crystal size distribution
  • consistent product quality

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