Continuous infusion of vancomycin in neonates

Anisa D. Patel, Dhullipala Anand, Carol Lucas, Alison Thomson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A one year, retrospective audit of intermittent vancomycin therapy within the Neonatal Unit at the Royal Hospital for Sick Children, Glasgow, found that only 33% of 984 vancomycin trough levels were within the British National Formulary for children (BNFc) target range of 10–15 mg/l and 25% were <10 mg/l. A detailed, prospective review of 20 courses (15 patients) over one month, while using the same dosing guidelines, highlighted that only 23 of 50 concentration measurements (46%) were within the target range and 20% were <10 mg/l, even though the initial doses used (table 1) were higher than those recommended by the BNFc. Dose adjustments were common and up to 80 mg/kg/day was often required for older infants. Appropriate interpretation of concentration results was compromised …
Original languageEnglish
Pages (from-to)478-479
Number of pages2
JournalArchives of Disease in Childhood
Volume98
Issue number6
Early online date30 Mar 2013
DOIs
Publication statusPublished - 30 Mar 2013

Keywords

  • vancomycin
  • pharmacokinetics
  • neonates

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