Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts

Vaclav Svoboda; Pól MacFhionnghaile; John McGinty; Lauren E. Connor; Iain D. H. Oswald; Jan Sefcik

doi:10.1021/acs.cgd.6b01866

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts

Vaclav Svoboda
, Pól MacFhionnghaile
, John McGinty
, Lauren E. Connor
, Iain D. H. Oswald
, Jan Sefcik

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

219 Downloads (Pure)

Abstract

This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.

Original language	English
Pages (from-to)	1902-1909
Number of pages	8
Journal	Crystal Growth and Design
Volume	17
Issue number	4
Early online date	13 Feb 2017
DOIs	https://doi.org/10.1021/acs.cgd.6b01866
Publication status	Published - 5 Apr 2017

Keywords

crystallization
reactive
antisolvent
mixing-induced supersaturation
cocrystals
benzoic acid
isonicotinamide

Access to Document

10.1021/acs.cgd.6b01866Licence: CC BY 4.0

Svoboda-etal-CGD-2017-Continuous-cocrystallization-of-benzoic-acid-and-isonicotinamideFinal published version, 6.01 MBLicence: CC BY 4.0

Cite this

@article{6b0a214918344ad5bdd47320a85c5d87,

title = "Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts",

abstract = "This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.",

keywords = "crystallization, reactive, antisolvent, mixing-induced supersaturation, cocrystals, benzoic acid, isonicotinamide",

author = "Vaclav Svoboda and P{\'o}l MacFhionnghaile and John McGinty and Connor, \{Lauren E.\} and Oswald, \{Iain D. H.\} and Jan Sefcik",

year = "2017",

month = apr,

day = "5",

doi = "10.1021/acs.cgd.6b01866",

language = "English",

volume = "17",

pages = "1902--1909",

journal = "Crystal Growth and Design",

issn = "1528-7483",

publisher = "American Chemical Society",

number = "4",

}

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts. / Svoboda, Vaclav; MacFhionnghaile, Pól; McGinty, John et al.
In: Crystal Growth and Design, Vol. 17, No. 4, 05.04.2017, p. 1902-1909.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation

T2 - exploring opportunities between reactive and antisolvent crystallization concepts

AU - Svoboda, Vaclav

AU - MacFhionnghaile, Pól

AU - McGinty, John

AU - Connor, Lauren E.

AU - Oswald, Iain D. H.

AU - Sefcik, Jan

PY - 2017/4/5

Y1 - 2017/4/5

N2 - This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.

AB - This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.

KW - crystallization

KW - reactive

KW - antisolvent

KW - mixing-induced supersaturation

KW - cocrystals

KW - benzoic acid

KW - isonicotinamide

UR - http://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b01866

U2 - 10.1021/acs.cgd.6b01866

DO - 10.1021/acs.cgd.6b01866

M3 - Article

SN - 1528-7483

VL - 17

SP - 1902

EP - 1909

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 4

ER -

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Pressure-Induced Nucleation for the Continuous Manufacture of Supramolecular assemblies

Doctoral Training Centre In Continuous Manufacturing And Crystallisation

CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

Cite this

Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Projects

Pressure-Induced Nucleation for the Continuous Manufacture of Supramolecular assemblies

Doctoral Training Centre In Continuous Manufacturing And Crystallisation

CMAC - EPSRC Centre for Innovative Manufacturing for Continuous Manufacturing and Crystallisation

Cite this