This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.
- mixing-induced supersaturation
- benzoic acid
Svoboda, V., MacFhionnghaile, P., McGinty, J., Connor, L. E., Oswald, I. D. H., & Sefcik, J. (2017). Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts. Crystal Growth and Design, 17(4), 1902-1909. https://doi.org/10.1021/acs.cgd.6b01866