Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation

exploring opportunities between reactive and antisolvent crystallization concepts

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Abstract

This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.
Original languageEnglish
Pages (from-to)1902-1909
Number of pages8
JournalCrystal Growth and Design
Volume17
Issue number4
Early online date13 Feb 2017
DOIs
Publication statusPublished - 5 Apr 2017

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Benzoic Acid
Benzoic acid
Supersaturation
benzoic acid
Crystallization
supersaturation
crystallization
experiment design
Design of experiments
isonicotinamide

Keywords

  • crystallization
  • reactive
  • antisolvent
  • mixing-induced supersaturation
  • cocrystals
  • benzoic acid
  • isonicotinamide

Cite this

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title = "Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts",
abstract = "This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.",
keywords = "crystallization, reactive, antisolvent, mixing-induced supersaturation, cocrystals, benzoic acid, isonicotinamide",
author = "Vaclav Svoboda and P{\'o}l MacFhionnghaile and John McGinty and Connor, {Lauren E.} and Oswald, {Iain D. H.} and Jan Sefcik",
year = "2017",
month = "4",
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language = "English",
volume = "17",
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journal = "Crystal Growth and Design",
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publisher = "American Chemical Society",
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T1 - Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation

T2 - exploring opportunities between reactive and antisolvent crystallization concepts

AU - Svoboda, Vaclav

AU - MacFhionnghaile, Pól

AU - McGinty, John

AU - Connor, Lauren E.

AU - Oswald, Iain D. H.

AU - Sefcik, Jan

PY - 2017/4/5

Y1 - 2017/4/5

N2 - This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.

AB - This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.

KW - crystallization

KW - reactive

KW - antisolvent

KW - mixing-induced supersaturation

KW - cocrystals

KW - benzoic acid

KW - isonicotinamide

UR - http://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b01866

U2 - 10.1021/acs.cgd.6b01866

DO - 10.1021/acs.cgd.6b01866

M3 - Article

VL - 17

SP - 1902

EP - 1909

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

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