Continuous cocrystallization of benzoic acid and isonicotinamide by mixing-induced supersaturation: exploring opportunities between reactive and antisolvent crystallization concepts

Vaclav Svoboda, Pól MacFhionnghaile, John McGinty, Lauren E. Connor, Iain D. H. Oswald, Jan Sefcik

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Abstract

This study combines reactive and antisolvent crystallization concepts via mixing-induced supersaturation to demonstrate a wider range of options for solvent system selection in multicomponent crystallization. This approach was applied to investigate continuous crystallization of 1:1 and 2:1 cocrystals of benzoic acid and isonicotinamide. Design of Experiments was used to identify conditions where pure cocrystal phases are obtained and a continuous mixing-induced cocrystallization process was implemented to selectively produce either 1:1 or 2:1 cocrystals.
Original languageEnglish
Pages (from-to)1902-1909
Number of pages8
JournalCrystal Growth and Design
Volume17
Issue number4
Early online date13 Feb 2017
DOIs
Publication statusPublished - 5 Apr 2017

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Keywords

  • crystallization
  • reactive
  • antisolvent
  • mixing-induced supersaturation
  • cocrystals
  • benzoic acid
  • isonicotinamide

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