Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug

Hiren Moradiya, Muhammad T. Islam, Grahame R. Woollam, Ian J. Slipper, Sheelagh Halsey, Martin J. Snowden, D. Douroumis

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A continuous manufacturing process, hot melt extrusion (HME), was employed for the development of high quality carbamazepine–saccharin (CBZ–SCH) cocrystals. The produced cocrystals were compared with a prototype prepared by a solvent method. It was found that processing parameters such as temperature, screw speed, and screw configuration were the critical processing parameters. In-line near-infrared analysis demonstrated that cocrystallization takes place gradually during the process along the extruder’s mixing zones. Further characterization of the extruded cocrystals proved that the manufactured highly crystalline cocrystals were similar to the prototype but had improved CBZ dissolution rates. Continuous manufacturing of cocrystals of water-insoluble drugs is a novel and robust approach.
Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalCrystal Growth and Design
Volume14
Issue number1
Early online date22 Nov 2013
DOIs
Publication statusPublished - 2 Jan 2014

Keywords

  • hot melt extrusion
  • dissolution rate
  • cocrystals
  • crystalline cocrystals

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