Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug

Hiren Moradiya, Muhammad T. Islam, Grahame R. Woollam, Ian J. Slipper, Sheelagh Halsey, Martin J. Snowden, D. Douroumis

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A continuous manufacturing process, hot melt extrusion (HME), was employed for the development of high quality carbamazepine–saccharin (CBZ–SCH) cocrystals. The produced cocrystals were compared with a prototype prepared by a solvent method. It was found that processing parameters such as temperature, screw speed, and screw configuration were the critical processing parameters. In-line near-infrared analysis demonstrated that cocrystallization takes place gradually during the process along the extruder’s mixing zones. Further characterization of the extruded cocrystals proved that the manufactured highly crystalline cocrystals were similar to the prototype but had improved CBZ dissolution rates. Continuous manufacturing of cocrystals of water-insoluble drugs is a novel and robust approach.
LanguageEnglish
Pages189-198
Number of pages10
JournalCrystal Growth and Design
Volume14
Issue number1
Early online date22 Nov 2013
DOIs
Publication statusPublished - 2 Jan 2014

Fingerprint

Saccharin
Carbamazepine
screws
dissolving
Dissolution
drugs
manufacturing
prototypes
optimization
Temperature
Water
Extruders
Processing
Pharmaceutical Preparations
water
Extrusion
Crystalline materials
Infrared radiation
configurations
temperature

Keywords

  • hot melt extrusion
  • dissolution rate
  • cocrystals
  • crystalline cocrystals

Cite this

Moradiya, H., Islam, M. T., Woollam, G. R., Slipper, I. J., Halsey, S., Snowden, M. J., & Douroumis, D. (2014). Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. Crystal Growth and Design, 14(1), 189-198. https://doi.org/10.1021/cg401375a
Moradiya, Hiren ; Islam, Muhammad T. ; Woollam, Grahame R. ; Slipper, Ian J. ; Halsey, Sheelagh ; Snowden, Martin J. ; Douroumis, D. / Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. In: Crystal Growth and Design. 2014 ; Vol. 14, No. 1. pp. 189-198.
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Moradiya, H, Islam, MT, Woollam, GR, Slipper, IJ, Halsey, S, Snowden, MJ & Douroumis, D 2014, 'Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug' Crystal Growth and Design, vol. 14, no. 1, pp. 189-198. https://doi.org/10.1021/cg401375a

Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. / Moradiya, Hiren; Islam, Muhammad T.; Woollam, Grahame R.; Slipper, Ian J.; Halsey, Sheelagh; Snowden, Martin J.; Douroumis, D.

In: Crystal Growth and Design, Vol. 14, No. 1, 02.01.2014, p. 189-198.

Research output: Contribution to journalArticle

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Moradiya H, Islam MT, Woollam GR, Slipper IJ, Halsey S, Snowden MJ et al. Continuous cocrystallization for dissolution rate optimization of a poorly water-soluble drug. Crystal Growth and Design. 2014 Jan 2;14(1):189-198. https://doi.org/10.1021/cg401375a