Constructing tissue-like complex structures using cell-laden DNA hydrogel bricks

Yijie Wang, Yu Shao, Xiaozhou Ma, Bini Zhou, Alan Faulkner-Jones, Wenmiao Shu, Dongsheng Liu

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)
144 Downloads (Pure)


Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new "brick-to-wall" based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.
Original languageEnglish
Pages (from-to)12311-12315
Number of pages5
JournalACS Applied Materials and Interfaces
Issue number14
Early online date16 Mar 2017
Publication statusE-pub ahead of print - 16 Mar 2017


  • DNA hydrogel
  • tissue engineering
  • cell arrangements
  • cell migration
  • self-healing
  • supramolecular


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