Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Robert M. Edkins; Elliott Hayden; Jonathan W. Steed; Katharina Fucke

doi:10.1039/c4cc10453f

Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Robert M. Edkins, Elliott Hayden, Jonathan W. Steed, Katharina Fucke

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

Original language	English
Pages (from-to)	5314-5317
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	25
DOIs	https://doi.org/10.1039/c4cc10453f
Publication status	Published - 28 Mar 2015

Keywords

tetrahydrocarbazolone derivatives
crystal form nucleation
conserved hydrogen bonding

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10.1039/c4cc10453f

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title = "Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation",

abstract = "Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form. ",

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AU - Hayden, Elliott

AU - Steed, Jonathan W.

AU - Fucke, Katharina

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KW - crystal form nucleation

KW - conserved hydrogen bonding

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