Conserved hydrogen bonding in tetrahydrocarbazolone derivatives: influence of solution-state assembly on crystal form nucleation

Robert M. Edkins, Elliott Hayden, Jonathan W. Steed, Katharina Fucke

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5 Citations (Scopus)


Two tetrahydocarbazolone derivatives were found to show multiple unsolvated crystal forms. A persistent dimer motif was detected in solution by FTIR spectroscopy that is maintained in the kinetic crystal forms. Rationally introduced steric bulk induces the formation of a more stable catemeric form.

Original languageEnglish
Pages (from-to)5314-5317
Number of pages4
JournalChemical Communications
Issue number25
Publication statusPublished - 28 Mar 2015



  • tetrahydrocarbazolone derivatives
  • crystal form nucleation
  • conserved hydrogen bonding

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