Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry

Sarah D. Brown, Duncan Graham

Research output: Contribution to journalArticle

18 Citations (Scopus)
174 Downloads (Pure)

Abstract

Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.
Original languageEnglish
Pages (from-to)5032-5034
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number38
DOIs
Publication statusPublished - 22 Sep 2010

Keywords

  • oligonucleotide peptide conjugates
  • Tat peptide
  • click chemistry

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