Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry

Sarah D. Brown, Duncan Graham

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.
LanguageEnglish
Pages5032-5034
Number of pages3
JournalTetrahedron Letters
Volume51
Issue number38
DOIs
Publication statusPublished - 22 Sep 2010

Fingerprint

Click Chemistry
Cell-Penetrating Peptides
Oligonucleotides
Therapeutics

Keywords

  • oligonucleotide peptide conjugates
  • Tat peptide
  • click chemistry

Cite this

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Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. / Brown, Sarah D.; Graham, Duncan.

In: Tetrahedron Letters, Vol. 51, No. 38, 22.09.2010, p. 5032-5034 .

Research output: Contribution to journalArticle

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