Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell penetrating peptide. Here we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.
- oligonucleotide peptide conjugates
- Tat peptide
- click chemistry
Brown, S. D., & Graham, D. (2010). Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry. Tetrahedron Letters, 51(38), 5032-5034 . https://doi.org/10.1016/j.tetlet.2010.07.101