Conjugate addition reactions

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Abstract

The conjugateadditionreaction is a fundamental process in organic chemistry. The reaction involves the addition of nucleophiles to acceptor substituted double and triple bonds and results in the formation of a new carbon-carbon, carbon-nitrogen, carbon-oxygen or carbon-sulfur bond. The reaction often leads to the generation of one, two or even three new stereogenic centres and so considerable effort has been made to develop catalytic asymmetric methods, particularly under the influence of an external chiral ligand or chiral catalyst. Indeed, over the past ten years there has been a plethora of such new methods, and this chapter adumbrates some of the major recent advances in this area. It also provides an overview of the arsenal of catalysts available to carry out this important class of synthetic reaction
LanguageEnglish
Title of host publicationSecond supplements to the 2nd edition of Rodd's chemistry of carbon compounds
Subtitle of host publicationa modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis
EditorsMalcolm Sainsbury
Pages199-258
Number of pages60
DOIs
Publication statusPublished - 2001

Fingerprint

Addition reactions
Carbon
Arsenals
Nucleophiles
Catalysts
Sulfur
Nitrogen
Oxygen
Ligands

Keywords

  • conjugate addition reactions
  • fundamental process
  • organic chemistry
  • nucleophiles
  • acceptor substituted double and triple bonds
  • carbon-carbon
  • carbon-nitrogen
  • carbon-oxygen

Cite this

Tomkinson, N. C. O. (2001). Conjugate addition reactions. In M. Sainsbury (Ed.), Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds: a modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis (pp. 199-258) https://doi.org/10.1016/B978-044453347-0.50422-5
Tomkinson, Nicholas C. O. / Conjugate addition reactions. Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds: a modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis. editor / Malcolm Sainsbury . 2001. pp. 199-258
@inbook{73bd52364cfe411c9d376a8a6d4d2929,
title = "Conjugate addition reactions",
abstract = "The conjugateadditionreaction is a fundamental process in organic chemistry. The reaction involves the addition of nucleophiles to acceptor substituted double and triple bonds and results in the formation of a new carbon-carbon, carbon-nitrogen, carbon-oxygen or carbon-sulfur bond. The reaction often leads to the generation of one, two or even three new stereogenic centres and so considerable effort has been made to develop catalytic asymmetric methods, particularly under the influence of an external chiral ligand or chiral catalyst. Indeed, over the past ten years there has been a plethora of such new methods, and this chapter adumbrates some of the major recent advances in this area. It also provides an overview of the arsenal of catalysts available to carry out this important class of synthetic reaction",
keywords = "conjugate addition reactions, fundamental process , organic chemistry, nucleophiles, acceptor substituted double and triple bonds , carbon-carbon, carbon-nitrogen, carbon-oxygen",
author = "Tomkinson, {Nicholas C. O.}",
year = "2001",
doi = "10.1016/B978-044453347-0.50422-5",
language = "English",
isbn = "9780444533470",
pages = "199--258",
editor = "{Sainsbury }, Malcolm",
booktitle = "Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds",

}

Tomkinson, NCO 2001, Conjugate addition reactions. in M Sainsbury (ed.), Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds: a modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis. pp. 199-258. https://doi.org/10.1016/B978-044453347-0.50422-5

Conjugate addition reactions. / Tomkinson, Nicholas C. O.

Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds: a modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis. ed. / Malcolm Sainsbury . 2001. p. 199-258.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

TY - CHAP

T1 - Conjugate addition reactions

AU - Tomkinson, Nicholas C. O.

PY - 2001

Y1 - 2001

N2 - The conjugateadditionreaction is a fundamental process in organic chemistry. The reaction involves the addition of nucleophiles to acceptor substituted double and triple bonds and results in the formation of a new carbon-carbon, carbon-nitrogen, carbon-oxygen or carbon-sulfur bond. The reaction often leads to the generation of one, two or even three new stereogenic centres and so considerable effort has been made to develop catalytic asymmetric methods, particularly under the influence of an external chiral ligand or chiral catalyst. Indeed, over the past ten years there has been a plethora of such new methods, and this chapter adumbrates some of the major recent advances in this area. It also provides an overview of the arsenal of catalysts available to carry out this important class of synthetic reaction

AB - The conjugateadditionreaction is a fundamental process in organic chemistry. The reaction involves the addition of nucleophiles to acceptor substituted double and triple bonds and results in the formation of a new carbon-carbon, carbon-nitrogen, carbon-oxygen or carbon-sulfur bond. The reaction often leads to the generation of one, two or even three new stereogenic centres and so considerable effort has been made to develop catalytic asymmetric methods, particularly under the influence of an external chiral ligand or chiral catalyst. Indeed, over the past ten years there has been a plethora of such new methods, and this chapter adumbrates some of the major recent advances in this area. It also provides an overview of the arsenal of catalysts available to carry out this important class of synthetic reaction

KW - conjugate addition reactions

KW - fundamental process

KW - organic chemistry

KW - nucleophiles

KW - acceptor substituted double and triple bonds

KW - carbon-carbon

KW - carbon-nitrogen

KW - carbon-oxygen

UR - http://www.sciencedirect.com/science/book/9780444533470

U2 - 10.1016/B978-044453347-0.50422-5

DO - 10.1016/B978-044453347-0.50422-5

M3 - Other chapter contribution

SN - 9780444533470

SP - 199

EP - 258

BT - Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds

A2 - Sainsbury , Malcolm

ER -

Tomkinson NCO. Conjugate addition reactions. In Sainsbury M, editor, Second supplements to the 2nd edition of Rodd's chemistry of carbon compounds: a modern comprehensive treatise. Volume 5 Part B: Asymmetric catalysis. 2001. p. 199-258 https://doi.org/10.1016/B978-044453347-0.50422-5