Concerted nucleophilic aromatic substitution reactions

Simon Rohrbach, Andrew J. Smith, Jia Hao Pang, Darren L. Poole, Tell Tuttle, Shunsuke Chiba, John A. Murphy

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)
1836 Downloads (Pure)


Recent developments in experimental and computational chemistry have identified a rapidly growing class of nucleophilic aromatic substitutions that proceed by concerted (cS NAr) rather than classical, two-step, S NAr mechanisms. Whereas traditional S NAr reactions require substantial activation of the aromatic ring by electron-withdrawing substituents, such activating groups are not mandatory in the concerted pathways.

Original languageEnglish
Pages (from-to)16368-16388
Number of pages21
JournalAngewandte Chemie International Edition
Issue number46
Early online date16 Apr 2019
Publication statusPublished - 11 Nov 2019


  • nucleophilic aromatic substitutions
  • substitution reactions
  • electron transfer


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