Computational modelling of the hybrid procedure in hypoplastic left heart syndrome: a comparison of zero-dimensional and three-dimensional approach.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint = 2 mm corresponded to dext = 3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics.

From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid–HLHS circulation.
LanguageEnglish
Pages1549-1553
Number of pages5
JournalMedical Engineering and Physics
Volume36
Issue number11
Early online date6 Oct 2014
DOIs
Publication statusPublished - Nov 2014

Fingerprint

Hypoplastic Left Heart Syndrome
Zero-dimensional
Computational Modeling
Hemodynamics
Three-dimensional
Cardiac Output
Pulmonary Artery
3D Model
Model
Oxygen
Pressure
Multiscale Model
3D Modeling
Arteries
Heart
Equivalence
Valid
Internal
Predict
Output

Keywords

  • Paediatric surgery
  • hypoplastic left heart
  • modelling

Cite this

@article{aef00179487b4a8f96e76957bd1799ce,
title = "Computational modelling of the hybrid procedure in hypoplastic left heart syndrome: a comparison of zero-dimensional and three-dimensional approach.",
abstract = "Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint = 2 mm corresponded to dext = 3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics.From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid–HLHS circulation.",
keywords = "Paediatric surgery, hypoplastic left heart, modelling",
author = "Andrew Young and Terry Gourlay and Sean McKee and Danton, {Mark H.D.}",
year = "2014",
month = "11",
doi = "10.1016/j.medengphy.2014.08.015",
language = "English",
volume = "36",
pages = "1549--1553",
journal = "Medical Engineering and Physics",
issn = "1350-4533",
number = "11",

}

TY - JOUR

T1 - Computational modelling of the hybrid procedure in hypoplastic left heart syndrome

T2 - Medical Engineering and Physics

AU - Young, Andrew

AU - Gourlay, Terry

AU - McKee, Sean

AU - Danton, Mark H.D.

PY - 2014/11

Y1 - 2014/11

N2 - Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint = 2 mm corresponded to dext = 3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics.From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid–HLHS circulation.

AB - Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint = 2 mm corresponded to dext = 3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics.From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid–HLHS circulation.

KW - Paediatric surgery

KW - hypoplastic left heart

KW - modelling

UR - http://www.sciencedirect.com/science/article/pii/S1350453314002239

U2 - 10.1016/j.medengphy.2014.08.015

DO - 10.1016/j.medengphy.2014.08.015

M3 - Article

VL - 36

SP - 1549

EP - 1553

JO - Medical Engineering and Physics

JF - Medical Engineering and Physics

SN - 1350-4533

IS - 11

ER -