Computational investigation in the aorta of children with Turner syndrome

Lauren Johnston, Ruth Allen, Pauline Hall-Barrientos, Avril Mason, Asimina Kazakidi

Research output: Contribution to conferenceAbstractpeer-review

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The aortic arch has complex flow dynamics, with locations of arterial curvature and bifurcation known to be prone to endothelial dysfunction one of the early biological markers for atherosclerotic lesions that underlie most cardiovascular disease. This is particularly relevant to conditions of obesity, which is believed to accelerate the initiation and progression of vascular changes. A computational investigation found morphological differences between the patient-specific geometries to have a strong effect on the haemodynamic environment, and low wall shear stress at areas where atherosclerotic lesions have been suggested to develop preferentially.
Original languageEnglish
Number of pages1
Publication statusPublished - 12 Dec 2019
EventCMALS One Health Workshop - University of Strathclyde, Glasgow, United Kingdom
Duration: 12 Dec 201912 Dec 2019


WorkshopCMALS One Health Workshop
Country/TerritoryUnited Kingdom


  • aortic arch
  • flow dynamics
  • cardiovascular disease
  • children
  • Turner syndrome


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