Computation of blood flow in the pulmonary bifurcation: towards a more effective treatment for adults with congenital heart disease

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

Abstract

Adults with congenital heart disease represent an increasing population of patients that require repeated surgical interventions, most commonly for pulmonary valve replacement (PVR) and stenting [1]. Currently, the decision for treatment relies on symptoms, including arrhythmias and abnormal right ventricular volume and function [2], however the optimal timing for surgery remains unclear [3]. The aim of this work is to investigate the altered haemodynamic environment of the pulmonary bifurcation in adults with repaired tetralogy of Fallot, before and after pulmonary valve replacement. The overall objective is to derive a computational fluid dynamic metric to determine the optimal time for surgery. In this preliminary study, we present results in simplified geometries of the pulmonary trunk, focusing on the effects of geometry and flow conditions.
LanguageEnglish
Title of host publicationBioMedEng18 Proceedings
Subtitle of host publicationThe UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers
Place of PublicationLondon
Number of pages1
Publication statusPublished - 7 Sep 2018
EventBioMedEng18 - Imperial College, London, United Kingdom
Duration: 6 Sep 20187 Sep 2018
https://www.biomedeng18.com/

Conference

ConferenceBioMedEng18
Abbreviated titleBioMedEng
CountryUnited Kingdom
CityLondon
Period6/09/187/09/18
Internet address

Fingerprint

Bifurcation (mathematics)
Surgery
Blood
Geometry
Hemodynamics
Computational fluid dynamics

Keywords

  • congenital heart disease
  • pulmonary valve replacement
  • pulmonary bifurcation
  • haemodynamic analysis

Cite this

Boumpouli, M., Danton, M., Gourlay, T., & Kazakidi, A. (2018). Computation of blood flow in the pulmonary bifurcation: towards a more effective treatment for adults with congenital heart disease. In BioMedEng18 Proceedings: The UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers London.
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abstract = "Adults with congenital heart disease represent an increasing population of patients that require repeated surgical interventions, most commonly for pulmonary valve replacement (PVR) and stenting [1]. Currently, the decision for treatment relies on symptoms, including arrhythmias and abnormal right ventricular volume and function [2], however the optimal timing for surgery remains unclear [3]. The aim of this work is to investigate the altered haemodynamic environment of the pulmonary bifurcation in adults with repaired tetralogy of Fallot, before and after pulmonary valve replacement. The overall objective is to derive a computational fluid dynamic metric to determine the optimal time for surgery. In this preliminary study, we present results in simplified geometries of the pulmonary trunk, focusing on the effects of geometry and flow conditions.",
keywords = "congenital heart disease, pulmonary valve replacement, pulmonary bifurcation, haemodynamic analysis",
author = "Maria Boumpouli and Mark Danton and Terry Gourlay and Asimina Kazakidi",
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Boumpouli, M, Danton, M, Gourlay, T & Kazakidi, A 2018, Computation of blood flow in the pulmonary bifurcation: towards a more effective treatment for adults with congenital heart disease. in BioMedEng18 Proceedings: The UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers. London, BioMedEng18, London, United Kingdom, 6/09/18.

Computation of blood flow in the pulmonary bifurcation : towards a more effective treatment for adults with congenital heart disease. / Boumpouli, Maria; Danton, Mark; Gourlay, Terry; Kazakidi, Asimina.

BioMedEng18 Proceedings: The UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers. London, 2018.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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N2 - Adults with congenital heart disease represent an increasing population of patients that require repeated surgical interventions, most commonly for pulmonary valve replacement (PVR) and stenting [1]. Currently, the decision for treatment relies on symptoms, including arrhythmias and abnormal right ventricular volume and function [2], however the optimal timing for surgery remains unclear [3]. The aim of this work is to investigate the altered haemodynamic environment of the pulmonary bifurcation in adults with repaired tetralogy of Fallot, before and after pulmonary valve replacement. The overall objective is to derive a computational fluid dynamic metric to determine the optimal time for surgery. In this preliminary study, we present results in simplified geometries of the pulmonary trunk, focusing on the effects of geometry and flow conditions.

AB - Adults with congenital heart disease represent an increasing population of patients that require repeated surgical interventions, most commonly for pulmonary valve replacement (PVR) and stenting [1]. Currently, the decision for treatment relies on symptoms, including arrhythmias and abnormal right ventricular volume and function [2], however the optimal timing for surgery remains unclear [3]. The aim of this work is to investigate the altered haemodynamic environment of the pulmonary bifurcation in adults with repaired tetralogy of Fallot, before and after pulmonary valve replacement. The overall objective is to derive a computational fluid dynamic metric to determine the optimal time for surgery. In this preliminary study, we present results in simplified geometries of the pulmonary trunk, focusing on the effects of geometry and flow conditions.

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Boumpouli M, Danton M, Gourlay T, Kazakidi A. Computation of blood flow in the pulmonary bifurcation: towards a more effective treatment for adults with congenital heart disease. In BioMedEng18 Proceedings: The UK's largest gathering of Biomedical Engineers, Medical Engineers and Bioengineers. London. 2018