Abstract
As a prelude to the study of the molecular recognition of DNA by anthracycline antibiotics, and as a basis for comparison with synthetic analogues the proton and carbon-13 NMR spectra of Aclacinomycin A in chloroform have been fully assigned and the likely solution conformation determined using COSY, HMQC and 1-D TOCSY and 1-D ROESY techniques. The D-ring of the fused tetracyclic ring system adopts a half-chair conformation and the sugar residues are shown to lie essentially in chair conformations with the glycosidic links diaxial. This imposes considerable restriction in the rotation about the glycosidic links.
Original language | English |
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Pages (from-to) | 7215-7222 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 51 |
Issue number | 26 |
DOIs | |
Publication status | Published - 26 Jun 1995 |
Keywords
- tetracyclic ring
- anthracycline antibiotics
- chloroform