Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya

Jilian O. Etenyi, Faith A. Okalebo, Sylvia A. Opanga, Kipruto A. Sinei, George O. Osanjo, Amanj Kurdi, Brian Godman

Research output: Contribution to conferenceAbstract

Abstract

Zidovudine and tenofovir form the back bone of antiretroviral therapy in Kenya, with sub-Sahara Africa having the highest prevalence of HIV worldwide. However, they have side effects which may adversely affect health related quality of life (HRQoL) and adherence. More women than men have HIV in sub-Sahara Africa; consequently, crucial to conduct studies in Africa. Objective: Compare the Health Related Quality of Life of adult patients on tenofovir versus zidovudine based regimens in a leading referral hospital in Kenya to guide future management decisions. Methods: Comparative cross sectional study conducted on adult out-patients on either tenofovir or zidovudine at Kenyatta National Hospital between 2015 and 2016. The Medical Outcome Study HIV Health Survey (MOS) was administered. Linear regression analysis was performed to identify determinants of HRQoL. Results: Of the total 501 patinets included, participants on zidovudine (39.9%, n=200) had a higher median Physical (PHS) and Mental Health Scores (MHS) (61.9, IQR: 59.5, 62.8) compared to those on tenofovir (60.1, IQR: 55.1, 62.3). Presence of any symptom of disease and stated inability to cope were negatively associated with PHS whilst having regular source of income improved PHS. Being on tenofovir, symptom of illness (β -1.24, 95 % CI; -2.253, -0.226), absence of pain (β 0.413, 95 % CI; 0.152, 0.674) and patient stated inability to cope with HIV (β -1.029, 95 % CI; -1.441, -0.617) affected the MHS. Patients on tenofovir and second line regimens also had more signs and symptoms of illness. Conclusion: Participants on zidovudine based regimens had a better performance across all aspects of HRQoL, and should be actively considered in the future where pertinent.

Conference

Conference34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management
CountryCzech Republic
CityPrague
Period22/08/1826/08/18

Fingerprint

Tenofovir
Zidovudine
Kenya
Quality of Life
HIV
Northern Africa
Mental Health
Health Surveys
Signs and Symptoms
Linear Models
Outpatients
Referral and Consultation
Cross-Sectional Studies
Regression Analysis
Outcome Assessment (Health Care)

Keywords

  • zidovudine
  • tenofovir
  • antiretroviral therapy
  • Kenya
  • sub Saharan Africa

Cite this

Etenyi, J. O., Okalebo, F. A., Opanga, S. A., Sinei, K. A., Osanjo, G. O., Kurdi, A., & Godman, B. (Accepted/In press). Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. Abstract from 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management , Prague, Czech Republic.
Etenyi, Jilian O. ; Okalebo, Faith A. ; Opanga, Sylvia A. ; Sinei, Kipruto A. ; Osanjo, George O. ; Kurdi, Amanj ; Godman, Brian. / Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. Abstract from 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management , Prague, Czech Republic.1 p.
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title = "Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya",
abstract = "Zidovudine and tenofovir form the back bone of antiretroviral therapy in Kenya, with sub-Sahara Africa having the highest prevalence of HIV worldwide. However, they have side effects which may adversely affect health related quality of life (HRQoL) and adherence. More women than men have HIV in sub-Sahara Africa; consequently, crucial to conduct studies in Africa. Objective: Compare the Health Related Quality of Life of adult patients on tenofovir versus zidovudine based regimens in a leading referral hospital in Kenya to guide future management decisions. Methods: Comparative cross sectional study conducted on adult out-patients on either tenofovir or zidovudine at Kenyatta National Hospital between 2015 and 2016. The Medical Outcome Study HIV Health Survey (MOS) was administered. Linear regression analysis was performed to identify determinants of HRQoL. Results: Of the total 501 patinets included, participants on zidovudine (39.9{\%}, n=200) had a higher median Physical (PHS) and Mental Health Scores (MHS) (61.9, IQR: 59.5, 62.8) compared to those on tenofovir (60.1, IQR: 55.1, 62.3). Presence of any symptom of disease and stated inability to cope were negatively associated with PHS whilst having regular source of income improved PHS. Being on tenofovir, symptom of illness (β -1.24, 95 {\%} CI; -2.253, -0.226), absence of pain (β 0.413, 95 {\%} CI; 0.152, 0.674) and patient stated inability to cope with HIV (β -1.029, 95 {\%} CI; -1.441, -0.617) affected the MHS. Patients on tenofovir and second line regimens also had more signs and symptoms of illness. Conclusion: Participants on zidovudine based regimens had a better performance across all aspects of HRQoL, and should be actively considered in the future where pertinent.",
keywords = "zidovudine, tenofovir, antiretroviral therapy, Kenya, sub Saharan Africa",
author = "Etenyi, {Jilian O.} and Okalebo, {Faith A.} and Opanga, {Sylvia A.} and Sinei, {Kipruto A.} and Osanjo, {George O.} and Amanj Kurdi and Brian Godman",
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note = "34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management ; Conference date: 22-08-2018 Through 26-08-2018",

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Etenyi, JO, Okalebo, FA, Opanga, SA, Sinei, KA, Osanjo, GO, Kurdi, A & Godman, B 2018, 'Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya' 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management , Prague, Czech Republic, 22/08/18 - 26/08/18, .

Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. / Etenyi, Jilian O.; Okalebo, Faith A.; Opanga, Sylvia A.; Sinei, Kipruto A.; Osanjo, George O.; Kurdi, Amanj; Godman, Brian.

2018. Abstract from 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management , Prague, Czech Republic.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya

AU - Etenyi, Jilian O.

AU - Okalebo, Faith A.

AU - Opanga, Sylvia A.

AU - Sinei, Kipruto A.

AU - Osanjo, George O.

AU - Kurdi, Amanj

AU - Godman, Brian

PY - 2018/5/8

Y1 - 2018/5/8

N2 - Zidovudine and tenofovir form the back bone of antiretroviral therapy in Kenya, with sub-Sahara Africa having the highest prevalence of HIV worldwide. However, they have side effects which may adversely affect health related quality of life (HRQoL) and adherence. More women than men have HIV in sub-Sahara Africa; consequently, crucial to conduct studies in Africa. Objective: Compare the Health Related Quality of Life of adult patients on tenofovir versus zidovudine based regimens in a leading referral hospital in Kenya to guide future management decisions. Methods: Comparative cross sectional study conducted on adult out-patients on either tenofovir or zidovudine at Kenyatta National Hospital between 2015 and 2016. The Medical Outcome Study HIV Health Survey (MOS) was administered. Linear regression analysis was performed to identify determinants of HRQoL. Results: Of the total 501 patinets included, participants on zidovudine (39.9%, n=200) had a higher median Physical (PHS) and Mental Health Scores (MHS) (61.9, IQR: 59.5, 62.8) compared to those on tenofovir (60.1, IQR: 55.1, 62.3). Presence of any symptom of disease and stated inability to cope were negatively associated with PHS whilst having regular source of income improved PHS. Being on tenofovir, symptom of illness (β -1.24, 95 % CI; -2.253, -0.226), absence of pain (β 0.413, 95 % CI; 0.152, 0.674) and patient stated inability to cope with HIV (β -1.029, 95 % CI; -1.441, -0.617) affected the MHS. Patients on tenofovir and second line regimens also had more signs and symptoms of illness. Conclusion: Participants on zidovudine based regimens had a better performance across all aspects of HRQoL, and should be actively considered in the future where pertinent.

AB - Zidovudine and tenofovir form the back bone of antiretroviral therapy in Kenya, with sub-Sahara Africa having the highest prevalence of HIV worldwide. However, they have side effects which may adversely affect health related quality of life (HRQoL) and adherence. More women than men have HIV in sub-Sahara Africa; consequently, crucial to conduct studies in Africa. Objective: Compare the Health Related Quality of Life of adult patients on tenofovir versus zidovudine based regimens in a leading referral hospital in Kenya to guide future management decisions. Methods: Comparative cross sectional study conducted on adult out-patients on either tenofovir or zidovudine at Kenyatta National Hospital between 2015 and 2016. The Medical Outcome Study HIV Health Survey (MOS) was administered. Linear regression analysis was performed to identify determinants of HRQoL. Results: Of the total 501 patinets included, participants on zidovudine (39.9%, n=200) had a higher median Physical (PHS) and Mental Health Scores (MHS) (61.9, IQR: 59.5, 62.8) compared to those on tenofovir (60.1, IQR: 55.1, 62.3). Presence of any symptom of disease and stated inability to cope were negatively associated with PHS whilst having regular source of income improved PHS. Being on tenofovir, symptom of illness (β -1.24, 95 % CI; -2.253, -0.226), absence of pain (β 0.413, 95 % CI; 0.152, 0.674) and patient stated inability to cope with HIV (β -1.029, 95 % CI; -1.441, -0.617) affected the MHS. Patients on tenofovir and second line regimens also had more signs and symptoms of illness. Conclusion: Participants on zidovudine based regimens had a better performance across all aspects of HRQoL, and should be actively considered in the future where pertinent.

KW - zidovudine

KW - tenofovir

KW - antiretroviral therapy

KW - Kenya

KW - sub Saharan Africa

UR - https://www.pharmacoepi.org/meetings/annual-conference/2018-icpe/

M3 - Abstract

ER -

Etenyi JO, Okalebo FA, Opanga SA, Sinei KA, Osanjo GO, Kurdi A et al. Comparison of zidovudine and tenofovir based regimens with regard to quality of life and prevalence of syptoms in HIV patients in Kenya. 2018. Abstract from 34th International Conference on Pharmacoepidemiology and Therapeutic Risk Management , Prague, Czech Republic.