TY - JOUR
T1 - Comparing the influence of exercise intensity on brain-derived neurotrophic factor serum levels in people with Parkinson’s disease
T2 - a pilot study
AU - O’Callaghan, Ailish
AU - Harvey, Marguerite
AU - Houghton, David
AU - Gray, William K.
AU - Weston, Kathryn L.
AU - Oates, Lloyd L.
AU - Romano, Barbara
AU - Walker , Richard W.
N1 - Funding Information: The MICT study was funded by a Parkinson’s UK innovation grant and a British Geriatrics Society SpR start-up grant. This HIIT study was funded by a grant from The Graham Wylie Foundation, UK. Speedflex Europe Ltd allowed use of their facilities and equipment free of charge. Neither the Graham Wylie Foundation, Speedflex Europe Ltd nor any employee of Speedflex Europe Ltd had any role in the design of the study, in data collection or analysis, in the writing of this manuscript, or in the decision to submit this manuscript for publication. Northumbria Healthcare NHS Foundation Trust acknowledges the support of the National Institute of Health Research Clinical Research Network (NIHR CRN).
Publisher Copyright: © 2019, Springer Nature Switzerland AG.
O’Callaghan, A., Harvey, M., Houghton, D. et al. Comparing the influence of exercise intensity on brain-derived neurotrophic factor serum levels in people with Parkinson’s disease: a pilot study. Aging Clin Exp Res 32, 1731–1738 (2020). https://doi.org/10.1007/s40520-019-01353-w
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Introduction: Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson’s disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a pilot study to investigate the role of exercise intensity on BDNF levels in people with PD. Methods: Participants of early- to mid-stage disease were recruited from a single PD service in north-east England, UK into two separate studies of exercise in PD, one involving moderate-intensity continuous training (MICT) and one involving high-intensity interval training (HIIT), both had control groups. In both the interventions, participants exercise three times per week for 12 weeks. Blood samples were taken for BDNF analysis at the start and end of the first session and the start and end of the final session, with corresponding samples taken in controls. Results: Data were available for 27 participants (13 intervention, 14 control) in the MICT intervention and 17 (9 intervention, 8 control) in the HIIT intervention. BDNF level did not rise significantly from the start to end of individual sessions. Across the 12 week period, they rose significantly in the HIIT intervention group, but not in controls or the MICT intervention group. Conclusions: High-intensity interval training appears to have a greater impact on BDNF than MICT. Future work should directly compare exercise modalities and investigate the impact of BDNF levels on disease progression and quality of life.
AB - Introduction: Endogenous brain-derived neurotrophic factor (BDNF) is thought to be protective against the neurodegeneration seen in Parkinson’s disease (PD), and is thought to increase during exercise. This has been proposed as a possible mechanism by which exercise improves outcomes for people with PD. We conducted a pilot study to investigate the role of exercise intensity on BDNF levels in people with PD. Methods: Participants of early- to mid-stage disease were recruited from a single PD service in north-east England, UK into two separate studies of exercise in PD, one involving moderate-intensity continuous training (MICT) and one involving high-intensity interval training (HIIT), both had control groups. In both the interventions, participants exercise three times per week for 12 weeks. Blood samples were taken for BDNF analysis at the start and end of the first session and the start and end of the final session, with corresponding samples taken in controls. Results: Data were available for 27 participants (13 intervention, 14 control) in the MICT intervention and 17 (9 intervention, 8 control) in the HIIT intervention. BDNF level did not rise significantly from the start to end of individual sessions. Across the 12 week period, they rose significantly in the HIIT intervention group, but not in controls or the MICT intervention group. Conclusions: High-intensity interval training appears to have a greater impact on BDNF than MICT. Future work should directly compare exercise modalities and investigate the impact of BDNF levels on disease progression and quality of life.
KW - brain-derived neurotrophic factor
KW - high-intensity exercise
KW - high-intensity interval training
KW - Parkinson’s disease
KW - physiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85074007363&partnerID=8YFLogxK
U2 - 10.1007/s40520-019-01353-w
DO - 10.1007/s40520-019-01353-w
M3 - Article
C2 - 31606860
AN - SCOPUS:85074007363
SN - 1594-0667
VL - 32
SP - 1731
EP - 1738
JO - Aging Clinical and Experimental Research
JF - Aging Clinical and Experimental Research
IS - 9
ER -