Comparing neutral (monometallic) and anionic (bimetallic) aluminium complexes in hydroboration catalysis: influences of lithium cooperation and ligand set

Research output: Contribution to journalArticle

Abstract

Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li–Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al−H bond, iBu2Al(TMP) operates as a masked hydride reducing benzophenone through a β‐Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.
LanguageEnglish
Number of pages6
JournalAngewandte Chemie International Edition
Early online date15 Jun 2018
DOIs
StateE-pub ahead of print - 15 Jun 2018

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Thymidine Monophosphate
Imines
Alkynes
Ketones
Aluminum
Catalysis
Lithium
Aldehydes
Libraries
Ligands
Catalysts
Hydrides
Catalyst activity
benzophenone
Substrates

Keywords

  • bimetallic lithium aluminates
  • neutral aluminium
  • hydroboration reactions
  • catalyst activity

Cite this

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title = "Comparing neutral (monometallic) and anionic (bimetallic) aluminium complexes in hydroboration catalysis: influences of lithium cooperation and ligand set",
abstract = "Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li–Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al−H bond, iBu2Al(TMP) operates as a masked hydride reducing benzophenone through a β‐Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.",
keywords = "bimetallic lithium aluminates, neutral aluminium, hydroboration reactions, catalyst activity",
author = "Pollard, {Victoria A.} and Fuentes, {M. {\`A}ngeles} and Kennedy, {Alan R.} and Ross McLellan and Mulvey, {Robert E.}",
year = "2018",
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doi = "10.1002/anie.201806168",
language = "English",
journal = "Angewandte Chemie International Edition",
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AU - Pollard,Victoria A.

AU - Fuentes,M. Àngeles

AU - Kennedy,Alan R.

AU - McLellan,Ross

AU - Mulvey,Robert E.

PY - 2018/6/15

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N2 - Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li–Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al−H bond, iBu2Al(TMP) operates as a masked hydride reducing benzophenone through a β‐Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.

AB - Bimetallic lithium aluminates and neutral aluminum counterparts are compared as catalysts in hydroboration reactions with aldehydes, ketones, imines and alkynes. Possessing Li–Al cooperativity, ate catalysts are found to be generally superior. Catalytic activity is also influenced by the ligand set, alkyl and/or amido. Devoid of an Al−H bond, iBu2Al(TMP) operates as a masked hydride reducing benzophenone through a β‐Η transfer process. This catalyst library therefore provides an entry point into the future design of Al catalysts targeting substrate specific transformations.

KW - bimetallic lithium aluminates

KW - neutral aluminium

KW - hydroboration reactions

KW - catalyst activity

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SN - 1433-7851

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