Comment on 'A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-square deconvolution with Laguerre expansion'

Yongliang Zhang, David Day-Uei Li

Research output: Contribution to journalComment/debate

1 Citation (Scopus)
16 Downloads (Pure)


This comment is to clarify that Poisson noise instead of Gaussian noise shall be included to assess the performances of least-squares deconvolution with Laguerre expansion (LSD-LE) for analysing fluorescence lifetime imaging (FLIM) data obtained from time-resolved systems. Moreover, we also corrected an equation in the paper. As the LSD-LE approach is rapid and has potential to be widely applied not only for diagnostic but for wider bioimaging applications, it is desirable to have precise noise models and equations.
Original languageEnglish
Pages (from-to)1632-1636
Number of pages5
JournalPhysics in Medicine and Biology
Issue number4
Publication statusPublished - 1 Feb 2017


  • Poisson noise
  • Gaussian noise
  • least-squares deconvolution
  • Laguerre expansion
  • fluorescence lifetime imaging
  • bioimaging
  • noise models

Cite this