Abstract
| Original language | English |
|---|---|
| Title of host publication | 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017) |
| Place of Publication | Swansea UK |
| Pages | 1011-1014 |
| Number of pages | 4 |
| Publication status | Published - 10 Apr 2017 |
| Event | 5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States Duration: 10 Apr 2017 → 12 Apr 2017 |
Conference
| Conference | 5th International Conference on Computational and Mathematical Biomedical Engineering |
|---|---|
| Country | United States |
| City | Pittsburgh |
| Period | 10/04/17 → 12/04/17 |
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Keywords
- Drug-eluting stents
- drug delivery
- coupled partial differential equations
- in-vivo experiments
Cite this
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Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. / McGinty, Sean; McCormick, Christopher; McKittrick, Craig Martin; Kennedy, Simon; Oldroyd, Keith G.; Wheel, Marcus; Scullion, Bryan ; Pontrelli, Giuseppe; McKee, Sean; Nithiarasu, P. (Editor); Robertson, A.M. (Editor).
5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK, 2017. p. 1011-1014.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution book
TY - GEN
T1 - Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics
AU - McGinty, Sean
AU - McCormick, Christopher
AU - McKittrick, Craig Martin
AU - Kennedy, Simon
AU - Oldroyd, Keith G.
AU - Wheel, Marcus
AU - Scullion, Bryan
AU - Pontrelli, Giuseppe
AU - McKee, Sean
A2 - Nithiarasu, P.
A2 - Robertson, A.M.
PY - 2017/4/10
Y1 - 2017/4/10
N2 - In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
AB - In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
KW - Drug-eluting stents
KW - drug delivery
KW - coupled partial differential equations
KW - in-vivo experiments
UR - http://www.compbiomed.net/2017/cmbe-proceedings.htm
M3 - Conference contribution book
SN - 9780956291448
SP - 1011
EP - 1014
BT - 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017)
CY - Swansea UK
ER -