Projects per year
Abstract
In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
Original language | English |
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Title of host publication | 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017) |
Place of Publication | Swansea UK |
Pages | 1011-1014 |
Number of pages | 4 |
Publication status | Published - 10 Apr 2017 |
Event | 5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States Duration: 10 Apr 2017 → 12 Apr 2017 |
Conference
Conference | 5th International Conference on Computational and Mathematical Biomedical Engineering |
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Abbreviated title | CMBE 2017 |
Country/Territory | United States |
City | Pittsburgh |
Period | 10/04/17 → 12/04/17 |
Keywords
- Drug-eluting stents
- drug delivery
- coupled partial differential equations
- in-vivo experiments
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Dive into the research topics of 'Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics'. Together they form a unique fingerprint.Projects
- 1 Finished
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Optimal design of drug-eluting stents
McGinty, S., McKee, S., McCormick, C., Wheel, M., Kennedy, S., Oldroyd, K. G. & McKittrick, C.
1/04/12 → 31/07/15
Project: Research
Datasets
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Data for: "Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance"
McKittrick, C. M. (Creator), McCormick, C. (Contributor), Wheel, M. (Contributor) & McKee, S. (Contributor), University of Strathclyde, 12 Mar 2019
DOI: 10.15129/af09df5c-a25d-4c8c-88d9-8a6df1d8213d
Dataset