Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics

Sean McGinty, Christopher McCormick, Craig Martin McKittrick, Simon Kennedy, Keith G. Oldroyd, Marcus Wheel, Bryan Scullion, Giuseppe Pontrelli, Sean McKee, P. Nithiarasu (Editor), A.M. Robertson (Editor)

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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Abstract

In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.
Original languageEnglish
Title of host publication5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017)
Place of PublicationSwansea UK
Pages1011-1014
Number of pages4
Publication statusPublished - 10 Apr 2017
Event5th International Conference on Computational and Mathematical Biomedical Engineering - Pittsburgh, Pittsburgh, United States
Duration: 10 Apr 201712 Apr 2017

Conference

Conference5th International Conference on Computational and Mathematical Biomedical Engineering
CountryUnited States
CityPittsburgh
Period10/04/1712/04/17

Fingerprint

Stents
Kinetics
Acrylics
Experiments
Mathematical models
Polymers

Keywords

  • Drug-eluting stents
  • drug delivery
  • coupled partial differential equations
  • in-vivo experiments

Cite this

McGinty, S., McCormick, C., McKittrick, C. M., Kennedy, S., Oldroyd, K. G., Wheel, M., ... Robertson, A. M. (Ed.) (2017). Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. In 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017) (pp. 1011-1014). Swansea UK.
McGinty, Sean ; McCormick, Christopher ; McKittrick, Craig Martin ; Kennedy, Simon ; Oldroyd, Keith G. ; Wheel, Marcus ; Scullion, Bryan ; Pontrelli, Giuseppe ; McKee, Sean ; Nithiarasu, P. (Editor) ; Robertson, A.M. (Editor). / Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK, 2017. pp. 1011-1014
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abstract = "In this paper we describe a combined in-vitro experimental and mathematical modelling approach to predict in-vivo drug-eluting stent kinetics. We coated stents with a mixture of sirolimus and a novel acrylic-based polymer in two different ratios. Our results indicate differential release kinetics between low and high drug dose formulations. Furthermore, mathematical model simulations of target receptor saturation suggest potential differences in efficacy.",
keywords = "Drug-eluting stents, drug delivery, coupled partial differential equations, in-vivo experiments",
author = "Sean McGinty and Christopher McCormick and McKittrick, {Craig Martin} and Simon Kennedy and Oldroyd, {Keith G.} and Marcus Wheel and Bryan Scullion and Giuseppe Pontrelli and Sean McKee and P. Nithiarasu and A.M. Robertson",
year = "2017",
month = "4",
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language = "English",
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McGinty, S, McCormick, C, McKittrick, CM, Kennedy, S, Oldroyd, KG, Wheel, M, Scullion, B, Pontrelli, G, McKee, S, Nithiarasu, P (ed.) & Robertson, AM (ed.) 2017, Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. in 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK, pp. 1011-1014, 5th International Conference on Computational and Mathematical Biomedical Engineering, Pittsburgh, United States, 10/04/17.

Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. / McGinty, Sean; McCormick, Christopher; McKittrick, Craig Martin; Kennedy, Simon; Oldroyd, Keith G.; Wheel, Marcus; Scullion, Bryan ; Pontrelli, Giuseppe; McKee, Sean; Nithiarasu, P. (Editor); Robertson, A.M. (Editor).

5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK, 2017. p. 1011-1014.

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

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McGinty S, McCormick C, McKittrick CM, Kennedy S, Oldroyd KG, Wheel M et al. Combining mathematical modelling with in-vitro experiments to predict in-vivo drug-eluting stent kinetics. In 5th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017). Swansea UK. 2017. p. 1011-1014