Cohort Profile : The COVID-19 in Pregnancy in Scotland (COPS) dynamic cohort of pregnant women to assess effects of viral and vaccine exposures on pregnancy

Sarah J Stock, Jade Carruthers, Cheryl Denny, Jack Donaghy, Anna Goulding, Lisa E M Hopcroft, Leanne Hopkins, Rachel Mulholland, Utkarsh Agrawal, Bonnie Auyeung, Srinivasa Vittal Katikireddi, Colin McCowan, Josie Murray, Chris Robertson, Aziz Sheikh, Ting Shi, Colin R Simpson, Eleftheria Vasileiou, Rachael Wood

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Abstract

COVID-19 in Pregnancy in Scotland (COPS) is a new national prospective dynamic cohort that was created to describe the epidemiology of COVID-19 in pregnancy and the effect of SARS-CoV-2 infection on pregnancy outcomes and to investigate the safety and effectiveness of COVID-19 vaccines among pregnant women.

The cohort links primary care records to maternity records, national birth and mortality records and other secondary health care data, together with laboratory results and vaccination information, thus providing a robust platform for the study of viral effects and pharmacoepidemiological research.

As of 16 September 2021, the dynamic cohort included 123 004 women with 134 070 completed or ongoing pregnancies. Pre-pandemic outcome rates for analyses can be calculated from an approved retrospective extension of the cohort to 1 January 2015.

Data are hosted in the Public Health Scotland’s (PHS) trusted research environment (TRE) and access may be granted via an enquiry to [phs.edris@phs.scot].
Original languageEnglish
JournalInternational Journal of Epidemiology
Early online date3 Jan 2022
DOIs
Publication statusE-pub ahead of print - 3 Jan 2022

Keywords

  • pregnancy
  • epidemiology
  • Covid-19
  • Scotland

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