Co-crystallisation at high pressure - an additional tool for the preparation and study of co-crystals

I.D.H. Oswald, C.R. Pulham

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Abstract

Crystallisation of paracetamol and piperazine from ethanol at a pressure of 0.57 GPa produced an ethanol solvate of a 2:1 co-crystal of paracetamol:piperazine. This contrasts with crystallisation from ethanol at ambient pressure for which only an unsolvated 2:1 co-crystal of paracetamol:piperazine has been obtained. The hydrogen bonding arrangements of the two compounds are very different and a striking feature of the solvate is the presence of an unusually short hydrogen bond between the phenolic and amine groups.
Original languageEnglish
Pages (from-to)1114-1116
Number of pages2
JournalCrystEngComm
Volume10
Issue number9
DOIs
Publication statusPublished - 2008

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Keywords

  • x-ray
  • polymorphs
  • paracetamol
  • diffraction
  • exploration
  • piracetam

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