Clinical applications of infrared and Raman spectroscopy: state of play and future challenges

Matthew J. Baker, Hugh J. Byrne, John Chalmers, Peter Gardner, Royston Goodacre, Alex Henderson, Sergei G. Kazarian, Francis L. Martin, Julian Moger, Nick Stone, Josep Sulé-Suso

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Vibrational spectroscopies, based on infrared absorption and/or Raman scattering provide a detailed fingerprint of a material, based on the chemical content. Diagnostic and prognostic tools based on these technologies have the potential to revolutionise our clinical systems leading to improved patient outcome, more efficient public services and significant economic savings. However, despite these strong drivers, there are many fundamental scientific and technological challenges which have limited the implementation of this technology in the clinical arena, although recent years have seen significant progress in addressing these challenges. This review examines (i) the state of the art of clinical applications of infrared absorption and Raman spectroscopy, and (ii) the outstanding challenges, and progress towards translation, highlighting specific examples in the areas of in vivo, ex vivo and in vitro applications. In addition, the requirements of instrumentation suitable for use in the clinic, strategies for pre-processing and statistical analysis in clinical spectroscopy and data sharing protocols, will be discussed. Emerging consensus recommendations are presented, and the future perspectives of the field are assessed, particularly in the context of national and international collaborative research initiatives, such as the UK EPSRC Clinical Infrared and Raman Spectroscopy Network, the EU COST Action Raman4Clinics, and the International Society for Clinical Spectroscopy.
LanguageEnglish
Number of pages23
JournalAnalyst
Early online date27 Feb 2018
DOIs
Publication statusE-pub ahead of print - 27 Feb 2018

Fingerprint

Raman Spectrum Analysis
Infrared absorption
Raman spectroscopy
infrared spectroscopy
Infrared spectroscopy
Spectrum Analysis
spectroscopy
Spectroscopy
Vibrational spectroscopy
Absorption spectroscopy
Technology
Raman scattering
Statistical methods
Information Dissemination
Dermatoglyphics
public service
atomic absorption spectroscopy
Economics
instrumentation
savings

Keywords

  • vibrational spectroscopies
  • Raman scattering
  • clinical systems
  • infrared absorption
  • Raman spectroscopy
  • clinical applications

Cite this

Baker, M. J., Byrne, H. J., Chalmers, J., Gardner, P., Goodacre, R., Henderson, A., ... Sulé-Suso, J. (2018). Clinical applications of infrared and Raman spectroscopy: state of play and future challenges. Analyst. https://doi.org/10.1039/C7AN01871A
Baker, Matthew J. ; Byrne, Hugh J. ; Chalmers, John ; Gardner, Peter ; Goodacre, Royston ; Henderson, Alex ; Kazarian, Sergei G. ; Martin, Francis L. ; Moger, Julian ; Stone, Nick ; Sulé-Suso, Josep. / Clinical applications of infrared and Raman spectroscopy : state of play and future challenges. In: Analyst. 2018.
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Baker, MJ, Byrne, HJ, Chalmers, J, Gardner, P, Goodacre, R, Henderson, A, Kazarian, SG, Martin, FL, Moger, J, Stone, N & Sulé-Suso, J 2018, 'Clinical applications of infrared and Raman spectroscopy: state of play and future challenges' Analyst. https://doi.org/10.1039/C7AN01871A

Clinical applications of infrared and Raman spectroscopy : state of play and future challenges. / Baker, Matthew J.; Byrne, Hugh J.; Chalmers, John; Gardner, Peter; Goodacre, Royston; Henderson, Alex; Kazarian, Sergei G.; Martin, Francis L.; Moger, Julian; Stone, Nick; Sulé-Suso, Josep.

In: Analyst, 27.02.2018.

Research output: Contribution to journalArticle

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