@inbook{240ba3834a1e435ba8bd3caa906ef048,
title = "Clearance of Leishmania donovani from the liver of BALB/c mice results in local resistance to re-infection.",
abstract = "Relapse occurs in 5–30% of cases of visceral leishmaniasis (Chulay et al., 1983; Sanyal and Arora, 1979). This could be caused either by treatment failure, or because patients become re-infected after successful chemotherapy. As the majority of individuals who acquire Leishmania donovani infections live in endemic areas, it is highly likely that they would be exposed to the parasite again, but what effect chemotheraphy has on the immunity of the host and resistance to re-infection has received little attention. However, it is well known that many of the immunological responses depressed during active infection are increased following chemotherapy. Thus after treatment patients develop positive responses in delayed hypersensitivity skin tests (Manson-Bahr, 1959) and their lymphocytes respond to in vitro Stimulation with specific antigen (Sacks et al., 1987).",
keywords = "visceral leishmaniasis, parasite burden, mycobacterium bovis, challenge infection, Muramyl Dipeptide",
author = "Carter, {K. C.} and Baillie, {A. J.} and J. Alexander and Dolan, {T. F.}",
year = "1989",
doi = "10.1007/978-1-4613-1575-9_128",
language = "English",
isbn = "9781461288626",
volume = "171",
series = "NATO-ASI Series A",
publisher = "Springer Science + Business Media",
pages = "993--999",
booktitle = "Leishmaniasis",
address = "United States",
}