Circuit mechanisms and computational models of REM sleep

Charlotte Héricé; Amisha Patel; Shuzo Sakata

doi:10.1016/j.neures.2018.08.003

Circuit mechanisms and computational models of REM sleep

Charlotte Héricé, Amisha Patel, Shuzo Sakata

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

Abstract

Rapid eye movement (REM) sleep or paradoxical sleep is an elusive behavioral state. Since its discovery in the 1950s, our knowledge of the neuroanatomy, neurotransmitters and neuropeptides underlying REM sleep regulation has continually evolved in parallel with the development of novel technologies. Although the pons was initially discovered to be responsible for REM sleep, it has since been revealed that many components in the hypothalamus, midbrain, pons, and medulla also contribute to REM sleep. In this review, we first provide an up-to-date overview of REM sleep-regulating circuits in the brainstem and hypothalamus by summarizing experimental evidence from neuroanatomical, neurophysiological and gain- and loss-of-function studies. Second, because quantitative approaches are essential for understanding the complexity of REM sleep-regulating circuits and because mathematical models have provided valuable insights into the dynamics underlying REM sleep genesis and maintenance, we summarize computational studies of the sleep-wake cycle, with an emphasis on REM sleep regulation. Finally, we discuss outstanding issues for future studies.

Language	English
Pages	1-32
Number of pages	32
Journal	Neuroscience Research
Early online date	15 Aug 2018
DOIs	10.1016/j.neures.2018.08.003
Publication status	E-pub ahead of print - 15 Aug 2018

Fingerprint

REM Sleep

Sleep

Pons

Hypothalamus

Neuroanatomy

Mesencephalon

Neuropeptides

Brain Stem

Neurotransmitter Agents

Theoretical Models

Maintenance

Technology

Keywords

REM sleep
brainstem
hypothalamus
computational model
cell type
brain state

Cite this

Héricé, C., Patel, A., & Sakata, S. (2018). Circuit mechanisms and computational models of REM sleep. Neuroscience Research, 1-32. https://doi.org/10.1016/j.neures.2018.08.003

Héricé, Charlotte ; Patel, Amisha ; Sakata, Shuzo. / Circuit mechanisms and computational models of REM sleep. In: Neuroscience Research. 2018 ; pp. 1-32.

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Héricé, C , Patel, A & Sakata, S 2018, 'Circuit mechanisms and computational models of REM sleep' Neuroscience Research, pp. 1-32. https://doi.org/10.1016/j.neures.2018.08.003

Circuit mechanisms and computational models of REM sleep. / Héricé, Charlotte ; Patel, Amisha ; Sakata, Shuzo.

In: Neuroscience Research, 15.08.2018, p. 1-32.

Research output: Contribution to journal › Article

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