Chronic toxicity of hexavalent chromium to U937 human monocyte cell line

V.K. Raghunathan, E.M. Ellis, M.H. Grant

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Abstract

Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.
Original languageEnglish
Publication statusPublished - 2006
EventBioScience 2006: Bioscience in the 21st Century - Glasgow, Scotland
Duration: 23 Jul 200627 Jul 2006

Conference

ConferenceBioScience 2006: Bioscience in the 21st Century
CityGlasgow, Scotland
Period23/07/0627/07/06

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Raghunathan, V. K., Ellis, E. M., & Grant, M. H. (2006). Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, .