Chronic toxicity of hexavalent chromium to U937 human monocyte cell line

V.K. Raghunathan, E.M. Ellis, M.H. Grant

Research output: Contribution to conferencePaper

Abstract

Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.

Conference

ConferenceBioScience 2006: Bioscience in the 21st Century
CityGlasgow, Scotland
Period23/07/0627/07/06

Fingerprint

Monocytes
Osteoblasts
Cell Line
Chromium Alloys
Glutathione Reductase
Poisons
Stainless Steel
Orthopedics
Glutathione
Metals
Macrophages
chromium hexavalent ion
In Vitro Techniques

Cite this

Raghunathan, V. K., Ellis, E. M., & Grant, M. H. (2006). Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, .
Raghunathan, V.K. ; Ellis, E.M. ; Grant, M.H. / Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, .
@conference{d35a23196b144e4a8d5333f8e37e20d2,
title = "Chronic toxicity of hexavalent chromium to U937 human monocyte cell line",
abstract = "Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.",
author = "V.K. Raghunathan and E.M. Ellis and M.H. Grant",
year = "2006",
language = "English",
note = "BioScience 2006: Bioscience in the 21st Century ; Conference date: 23-07-2006 Through 27-07-2006",

}

Raghunathan, VK, Ellis, EM & Grant, MH 2006, 'Chronic toxicity of hexavalent chromium to U937 human monocyte cell line' Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, 23/07/06 - 27/07/06, .

Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. / Raghunathan, V.K.; Ellis, E.M.; Grant, M.H.

2006. Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, .

Research output: Contribution to conferencePaper

TY - CONF

T1 - Chronic toxicity of hexavalent chromium to U937 human monocyte cell line

AU - Raghunathan, V.K.

AU - Ellis, E.M.

AU - Grant, M.H.

PY - 2006

Y1 - 2006

N2 - Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.

AB - Cobalt chromium (CoCr) alloy and stainless steel are widely used in orthopaedic implants. Cr(VI) is known to be released when metals corrode in vivo (Milošev et al., 2005) and may be toxic to local cells like osteoblasts and macrophages. Ning and Grant, 2000 J. Ning and M.H. Grant, Toxicol. In Vitro 14 (2000), pp. 329-335. Article | PDF (185 K)(25)Ning and Grant (2000) have demonstrated the acute toxicity of Cr(VI) to immortalised rat osteoblasts and shown the involvement of reduced glutathione (GSH) and glutathione reductase (GRd) in the interaction. This paper details the chronic toxicity of hexavalent chromium to U937 human monocyte cell lines.

UR - http://www.bioscience2006.org/programme/default.htm

UR - http://www.biochemistry.org/

UR - http://dx.doi.org/10.1016/j.tox.2006.11.030

M3 - Paper

ER -

Raghunathan VK, Ellis EM, Grant MH. Chronic toxicity of hexavalent chromium to U937 human monocyte cell line. 2006. Paper presented at BioScience 2006: Bioscience in the 21st Century, Glasgow, Scotland, .