Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

Jing Xu, Julia Kjer, Jandirk Sendker, Victor Wray, Huashi Guan, RuAngelie Edrada-Ebel, Wenhan Lin, Jun Wu, Peter Proksch

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.
LanguageEnglish
Pages662-665
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number4
DOIs
Publication statusPublished - Apr 2009

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Rhizophoraceae
Chromones
Fungi
Mycelium
Cytotoxicity
Cells
Derivatives
Cell Line
Neoplasms

Keywords

  • chromones
  • endophytic fungus
  • pestalotiopsis sp
  • chinese mangrove plant
  • rhizophora mucronata
  • pharmacology

Cite this

Xu, Jing ; Kjer, Julia ; Sendker, Jandirk ; Wray, Victor ; Guan, Huashi ; Edrada-Ebel, RuAngelie ; Lin, Wenhan ; Wu, Jun ; Proksch, Peter. / Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. In: Journal of Natural Products. 2009 ; Vol. 72, No. 4. pp. 662-665.
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Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. / Xu, Jing; Kjer, Julia; Sendker, Jandirk; Wray, Victor; Guan, Huashi; Edrada-Ebel, RuAngelie; Lin, Wenhan; Wu, Jun; Proksch, Peter.

In: Journal of Natural Products, Vol. 72, No. 4, 04.2009, p. 662-665.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

AU - Xu, Jing

AU - Kjer, Julia

AU - Sendker, Jandirk

AU - Wray, Victor

AU - Guan, Huashi

AU - Edrada-Ebel, RuAngelie

AU - Lin, Wenhan

AU - Wu, Jun

AU - Proksch, Peter

PY - 2009/4

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AB - Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.

KW - chromones

KW - endophytic fungus

KW - pestalotiopsis sp

KW - chinese mangrove plant

KW - rhizophora mucronata

KW - pharmacology

U2 - 10.1021/np800748u

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