Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

Jing Xu, Julia Kjer, Jandirk Sendker, Victor Wray, Huashi Guan, RuAngelie Edrada-Ebel, Wenhan Lin, Jun Wu, Peter Proksch

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.
Original languageEnglish
Pages (from-to)662-665
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • chromones
  • endophytic fungus
  • pestalotiopsis sp
  • chinese mangrove plant
  • rhizophora mucronata
  • pharmacology

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