Chromatographic performance of molecularly imprinted polymers: Core-shell microspheres by precipitation polymerization and grafted MIP films via iniferter-modified silica beads

Francisco Barahona, Esther Turiel, Peter A. G. Cormack, Antonio. Martin-Esteban

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

In this work, two different surface imprinting formats have been evaluated using thiabendazole (TBZ) as model template. The first format is a thin film of molecularly imprinted polymer (MIP) grafted from preformed silica particles using an immobilized iniferter-type initiator (inif-MIP). The second format is molecularly imprinted polymer microspheres with narrow particle size distribution and core-shell morphol. prepd. by pptn. polymn. in a two-step procedure. For the latter format, polymer microspheres (the core particles) were obtained by pptn. polymn. of divinylbenzene-80 (DVB-80) in acetonitrile. Thereafter, the core particles were used as seed particles in the synthesis of MIP shells by copolymn. of DVB-80 and methacrylic acid in the presence of TBZ in a mixed solvent porogen (acetonitrile/toluene). The materials were characterized by elemental microanal., nitrogen sorption porosimetry and scanning (and transmission) electron microscopy. Thereafter, the imprinted materials were assessed as stationary phases in liq. chromatog. From this study it can be concluded that grafted MIP beads can be obtained in a simple and direct manner, consuming only a fraction of the reagents used typically to prep. imprinted particles from a monolithic imprinted polymer. Such materials can be used in the development of in-line molecularly imprinted solid-phase extn. methods. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1058-1066, 2010.
LanguageUndefined/Unknown
Pages1058-1066
Number of pages9
JournalJournal of Polymer Science Part A: Polymer Chemistry
Volume48
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • polymers
  • microspheres
  • polymerization
  • silica beads

Cite this

@article{b15ce8dbc7994072adaa1417d53fabd7,
title = "Chromatographic performance of molecularly imprinted polymers: Core-shell microspheres by precipitation polymerization and grafted MIP films via iniferter-modified silica beads",
abstract = "In this work, two different surface imprinting formats have been evaluated using thiabendazole (TBZ) as model template. The first format is a thin film of molecularly imprinted polymer (MIP) grafted from preformed silica particles using an immobilized iniferter-type initiator (inif-MIP). The second format is molecularly imprinted polymer microspheres with narrow particle size distribution and core-shell morphol. prepd. by pptn. polymn. in a two-step procedure. For the latter format, polymer microspheres (the core particles) were obtained by pptn. polymn. of divinylbenzene-80 (DVB-80) in acetonitrile. Thereafter, the core particles were used as seed particles in the synthesis of MIP shells by copolymn. of DVB-80 and methacrylic acid in the presence of TBZ in a mixed solvent porogen (acetonitrile/toluene). The materials were characterized by elemental microanal., nitrogen sorption porosimetry and scanning (and transmission) electron microscopy. Thereafter, the imprinted materials were assessed as stationary phases in liq. chromatog. From this study it can be concluded that grafted MIP beads can be obtained in a simple and direct manner, consuming only a fraction of the reagents used typically to prep. imprinted particles from a monolithic imprinted polymer. Such materials can be used in the development of in-line molecularly imprinted solid-phase extn. methods. {\circledC} 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1058-1066, 2010.",
keywords = "polymers , microspheres , polymerization , silica beads",
author = "Francisco Barahona and Esther Turiel and Cormack, {Peter A. G.} and Antonio. Martin-Esteban",
year = "2010",
doi = "10.1002/pola.23860",
language = "Undefined/Unknown",
volume = "48",
pages = "1058--1066",
journal = "Journal of Polymer Science Part A: Polymer Chemistry",
issn = "0887-624X",
number = "5",

}

TY - JOUR

T1 - Chromatographic performance of molecularly imprinted polymers: Core-shell microspheres by precipitation polymerization and grafted MIP films via iniferter-modified silica beads

AU - Barahona, Francisco

AU - Turiel, Esther

AU - Cormack, Peter A. G.

AU - Martin-Esteban, Antonio.

PY - 2010

Y1 - 2010

N2 - In this work, two different surface imprinting formats have been evaluated using thiabendazole (TBZ) as model template. The first format is a thin film of molecularly imprinted polymer (MIP) grafted from preformed silica particles using an immobilized iniferter-type initiator (inif-MIP). The second format is molecularly imprinted polymer microspheres with narrow particle size distribution and core-shell morphol. prepd. by pptn. polymn. in a two-step procedure. For the latter format, polymer microspheres (the core particles) were obtained by pptn. polymn. of divinylbenzene-80 (DVB-80) in acetonitrile. Thereafter, the core particles were used as seed particles in the synthesis of MIP shells by copolymn. of DVB-80 and methacrylic acid in the presence of TBZ in a mixed solvent porogen (acetonitrile/toluene). The materials were characterized by elemental microanal., nitrogen sorption porosimetry and scanning (and transmission) electron microscopy. Thereafter, the imprinted materials were assessed as stationary phases in liq. chromatog. From this study it can be concluded that grafted MIP beads can be obtained in a simple and direct manner, consuming only a fraction of the reagents used typically to prep. imprinted particles from a monolithic imprinted polymer. Such materials can be used in the development of in-line molecularly imprinted solid-phase extn. methods. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1058-1066, 2010.

AB - In this work, two different surface imprinting formats have been evaluated using thiabendazole (TBZ) as model template. The first format is a thin film of molecularly imprinted polymer (MIP) grafted from preformed silica particles using an immobilized iniferter-type initiator (inif-MIP). The second format is molecularly imprinted polymer microspheres with narrow particle size distribution and core-shell morphol. prepd. by pptn. polymn. in a two-step procedure. For the latter format, polymer microspheres (the core particles) were obtained by pptn. polymn. of divinylbenzene-80 (DVB-80) in acetonitrile. Thereafter, the core particles were used as seed particles in the synthesis of MIP shells by copolymn. of DVB-80 and methacrylic acid in the presence of TBZ in a mixed solvent porogen (acetonitrile/toluene). The materials were characterized by elemental microanal., nitrogen sorption porosimetry and scanning (and transmission) electron microscopy. Thereafter, the imprinted materials were assessed as stationary phases in liq. chromatog. From this study it can be concluded that grafted MIP beads can be obtained in a simple and direct manner, consuming only a fraction of the reagents used typically to prep. imprinted particles from a monolithic imprinted polymer. Such materials can be used in the development of in-line molecularly imprinted solid-phase extn. methods. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 1058-1066, 2010.

KW - polymers

KW - microspheres

KW - polymerization

KW - silica beads

UR - http://www.scopus.com/inward/record.url?scp=76249131742&partnerID=8YFLogxK

U2 - 10.1002/pola.23860

DO - 10.1002/pola.23860

M3 - Article

VL - 48

SP - 1058

EP - 1066

JO - Journal of Polymer Science Part A: Polymer Chemistry

T2 - Journal of Polymer Science Part A: Polymer Chemistry

JF - Journal of Polymer Science Part A: Polymer Chemistry

SN - 0887-624X

IS - 5

ER -